Autopharmacology

Source: Wikipedia, the free encyclopedia.

Autopharmacology relates to the

endorphins, which, as its name implies, were discovered to exist in the brain and have specific receptors in it,[2] by investigations on the mechanism of action of opioids, such as morphine
.

Historically, the first approach to the concept of autopharmacology began with

Nobel Prize for Physiology or Medicine
for their pioneering and important contributions.

A research area where autopharmacology principles assumed great importance was that of

therapeutic drugs
.

Endogenous substances that could fall under the concept of autopharmacology are:

The main scientific criterion for an autopharmacological agent is the discovery of specific membrane receptors for it and, hopefully, its transduction and cell signaling mechanisms.

The term was never much of a mainstream concept, and has fallen into disuse, as research on basic mechanisms has advanced. In a recent literature search on PubMed, only six titles refer to the term autopharmacology.

References

  1. OCLC 459029325
  2. ISBN 0-684-84634-9
  3. ^ Tansey, T: Sir Henry Dale and autopharmacology: the role of acetylcholine in neurotransmission. Clio Med. 1995;33:179-93.
  4. ^ Leme, J.G. Regulatory mechanisms in inflammation: new aspects of autopharmacology. General Pharmacology 02/1981; 12(1):15-24.
  5. ^ Hawgood B.J. Mauricio Rocha e Silva MD : Snake venom, bradykinin and the rise of autopharmacology. Toxicon 1997, vol. 35, no11, pp. 1569-1580 (1 p.1/2) Abstract
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