BCL2-related protein A1
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| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 15: 79.96 – 79.97 Mb | Chr 9: 88.61 – 88.61 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Bcl-2-related protein A1 is a protein in humans which is encoded by the BCL2A1 gene.[5][6][7]
Function
This gene encodes a member of the
IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.[7]
In melanocytic cells BCL2A1 gene expression may be regulated by MITF.[8]
Interactions
BCL2-related protein A1 has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000140379 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000099974 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8589678.
- PMID 12771180.
- ^ a b "Entrez Gene: BCL2A1 BCL2-related protein A1".
- PMID 19067971.
- PMID 7644501.
- PMID 10753914.
- S2CID 23119757.
- PMID 15694340.
External links
- Human BCL2A1 genome location and BCL2A1 gene details page in the UCSC Genome Browser.
Further reading
- Choi SS, Park IC, Yun JW, et al. (1995). "A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow". Oncogene. 11 (9): 1693–8. PMID 7478596.
- Lin EY, Orlofsky A, Berger MS, Prystowsky MB (1993). "Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2". J. Immunol. 151 (4): 1979–88. S2CID 22930599.
- Karsan A, Yee E, Kaushansky K, Harlan JM (1996). "Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells". Blood. 87 (8): 3089–96. PMID 8605321.
- Karsan A, Yee E, Harlan JM (1996). "Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1". J. Biol. Chem. 271 (44): 27201–4. PMID 8910286.
- Carrió R, López-Hoyos M, Jimeno J, et al. (1997). "A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death". Am. J. Pathol. 149 (6): 2133–42. PMID 8952545.
- Kenny JJ, Knobloch TJ, Augustus M, et al. (1997). "GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes". Oncogene. 14 (8): 997–1001. S2CID 365249.
- Choi SS, Park SH, Kim UJ, Shin HS (1997). "Bfl-1, a Bcl-2-related gene, is the human homolog of the murine A1, and maps to chromosome 15q24.3". Mamm. Genome. 8 (10): 781–2. S2CID 8472273.
- Hsu SY, Kaipia A, McGee E, et al. (1997). "Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12401–6. PMID 9356461.
- Takemoto Y, Furuta M, Sato M, et al. (1998). "Growth factor receptor-bound protein 2 (Grb2) association with hemopoietic specific protein 1: linkage between Lck and Grb2". J. Immunol. 161 (2): 625–30. S2CID 11576096.
- Zong WX, Edelstein LC, Chen C, et al. (1999). "The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis". Genes Dev. 13 (4): 382–7. PMID 10049353.
- Holmgreen SP, Huang DC, Adams JM, Cory S (1999). "Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members". Cell Death Differ. 6 (6): 525–32. PMID 10381646.
- Lee HH, Dadgostar H, Cheng Q, et al. (1999). "NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 9136–41. PMID 10430908.
- Wang CY, Guttridge DC, Mayo MW, Baldwin AS (1999). "NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis". Mol. Cell. Biol. 19 (9): 5923–9. PMID 10454539.
- Tomayko MM, Punt JA, Bolcavage JM, et al. (1999). "Expression of the Bcl-2 family member A1 is developmentally regulated in T cells". Int. Immunol. 11 (11): 1753–61. PMID 10545479.
- Zhang H, Cowan-Jacob SW, Simonen M, et al. (2000). "Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells". J. Biol. Chem. 275 (15): 11092–9. PMID 10753914.
- Duriez PJ, Wong F, Dorovini-Zis K, et al. (2000). "A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor". J. Biol. Chem. 275 (24): 18099–107. PMID 10849436.
- Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. S2CID 25064683.
- Bae J, Hsu SY, Leo CP, et al. (2001). "Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis". Apoptosis. 6 (5): 319–30. S2CID 23119757.
- Akari H, Bour S, Kao S, et al. (2001). "The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors". J. Exp. Med. 194 (9): 1299–311. PMID 11696595.
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