BW-A444
 | This article relies largely or entirely on a single source. (October 2014) |
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BW A444U was an experimental
neuromuscular-blocking drugs, intended to be used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation
. It was synthesized and developed in the early 1980s.
BW A444U represented the first-generation of
Research Triangle Park, NC) in collaboration with John J. Savarese MD (who at the time was an anesthesiologist in the Dept. of Anesthesia, Harvard Medical School at the Massachusetts General Hospital, Boston
, MA).
The drug was tested clinically in the early 1980s,[1] and quickly abandoned from further clinical development after a single clinical study, owing primarily to undesirable effects of histamine release when administered at clinically relevant doses.
References
- ^ S2CID 22212818.