Bitolterol

Source: Wikipedia, the free encyclopedia.
Bitolterol
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa601236
ATC code
Identifiers
  • (RS)-[4-(1-Hydroxy-2-tert-butylamino-ethyl)-2-(4-methylbenzoyl)oxy-phenyl] 4-methylbenzoate
JSmol)
ChiralityRacemic mixture
  • O=C(Oc2cc(ccc2OC(=O)c1ccc(cc1)C)C(O)CNC(C)(C)C)c3ccc(cc3)C

Bitolterol mesylate (Tornalate) is a short-acting

β2 adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma[1][2] and COPD.[3][4][5]
In these disorders there is a narrowing of the airways (bronchi and their ramifications) that carry air to the lungs. Muscle spasm and inflammation within the bronchi worsen this narrowing. Bitolterol relaxes the smooth muscles present continuously around the bronchi and bronchioles facilitating the flow of air through them.

Colterol

Bitolterol is a prodrug of colterol.[6][7] It has a rapid onset of action (2–5 minutes) and may last up to 6–8 hours.[8] The drug, alone or in co-administration with theophylline, doesn't show cardiotoxic effect.[9]

The U.S. Food and Drug Administration (FDA) approved bitolterol in December 1984. The drug was withdrawn from the market by Élan Pharmaceuticals in 2001.

References

  1. PMID 3717716
    .
  2. PMID 3571773
    .
  3. S2CID 218471864. Archived from the original
    on 2012-12-23.
  4. PMID 396832
    .
  5. PMID 6380974
    .
  6. S2CID 29431526
    .
  7. ^ "ChEBI: Bitolterol". Chemical Entities of Biological Interest. Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK. Retrieved 27 March 2016.
  8. PMID 6995040
    .
  9. PMID 6693665
    .
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