Blood–retinal barrier
The blood–retinal barrier, or the BRB, is part of the
choriocapillaris into the retina
.
Structure
The blood retinal barrier has two components: the
eyeball. The retinal pigment epithelium maintains the outer blood–retinal barrier.[3]
Clinical significance
Diabetic retinopathy
Diabetic retinopathy, eye damage that frequently occurs as a result of diabetes, is related to the breakdown of the blood–retinal barrier.[4] The barrier becomes more leaky in patients with diabetic retinopathy.[5]
Other animals
Animal models have shown that the blood–retinal barrier becomes more permeable to substances in hypertensive animals (those with high blood pressure).[6]
See also
- Blood–air barrier – Membrane separating alveolar air from blood in lung capillaries
- Blood–brain barrier – Semipermeable capillary border that allows selective passage of blood constituents into the brain
- Blood–ocular barrier – Physical barrier between the local blood vessels and most parts of the eye itself
- Blood–saliva barrier – Semipermeable biological barrier
- Blood–testis barrier – Physical barrier between the blood vessels and the seminiferous tubules of animal testes
- Blood–thymus barrier – Barrier formed by the continuous blood capillaries in the thymic cortex
References
- ^ Biologyonline.org. Blood–retinal barrier[permanent dead link]. Retrieved on July 19, 2007.
- PMID 7756735.
- ^ Pardianto, G; et al. (2005). "Blood–retinal-barrier". Mimbar Ilmiah Oftalmologi Indonesia. 2: 68–69.
- ^ Azza B. El-Remessy, Mohamed Al-Shabrawey, Yousuf Khalifa, Nai-Tse Tsai, Ruth B. Caldwell and Gregory I. Liou. 2006. Neuroprotective and Blood–retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes. American Journal of Pathology, Volume 168, Pages 235-244. Retrieved on July 19, 2007.
- PMID 11030818.
- ^ S Lightman, E Rechthand, C Latker, A Palestine and S Rapoport. Assessment of the permeability of the blood–retinal barrier in hypertensive rats. Hypertension, Volume 10, Pages 390-395. Retrieved on July 19, 2007.