Brugia timori
Brugia timori | |
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Infectious disease |
Brugia timori is a
Brugia timori | |
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Scientific classification | |
Domain: | Eukaryota |
Kingdom: | Animalia |
Phylum: | Nematoda |
Class: | Chromadorea |
Order: | Rhabditida |
Family: | Onchocercidae |
Genus: | Brugia |
Species: | B. timori
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Binomial name | |
Brugia timori Partono et al. 1977
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Signs and symptoms
Like other human filariasis infections, Brugia timori filariasis causes acute fever and chronic lymphedema. The life cycle of Brugia timori is very similar to that of Wuchereria bancrofti and Brugia malayi, leading to nocturnal periodicity of the disease symptoms. Eosinophilia is common during acute stages of infection.[citation needed]
So far Brugia timori has only been found in the
Parasite
The microfilariae of Brugia timori are longer and morphologically distinct from those of Brugia malayi and Wuchereria bancrofti, with a
Life cycle
The life cycle is:[7]
- During feeding, mosquitos ingest the infective filariform from an infected host
- Inside the mosquito the microfilariae penetrate the midgut and migrate to muscle tissue to grow and undergo two molts into infective filariform larvae (no sexual reproduction occurs within the mosquito)
- The filariform larvae will migrate to the mouthparts of the mosquito
- Larvae enter the host's circulation and migrate to lymphatic vessels where they develop into microfilariae-producing adults. Here the adults can live for several years
- The infective filariform enter the circulation of the host to repeat the life cycle
Morphology
B. timori microfilariae have nuclei that extend to the tip of the tail, which is also characteristic of B. malayi but not W. bancrofti.[5] B. timori microfilariae are slightly larger than B. malayi microfilariae.[5]
Endosymbiont
Aside from vectoring Brugia species, mosquitoes also maintain Wolbachia spp. which has been found to be an obligate intracellular bacterial endosymbiont of Brugia spp.[7] Wolbachia supports essential biochemical pathways necessary for the survival of Brugia, especially processes such as embryogenesis and molting.[7]
Treatment
See also
- List of parasites (human)
References
- PMID 14345284.
- PMID 864573.
- PMID 15122.
- PMID 12201590.
- ^ a b c "Lymphatic Filariasis Endemic Countries and Territories." Lymphatic Filariasis Disease. May 2006. The Carter Center. 13 May 2006.
- PMID 22593.
- ^ a b c LeAnne M Fox; Christopher L King (2013). "110 - Lymphatic Filariasis". In Alan J Magill; David R Hill; Tom Solomon; Edward T Ryan (eds.). Hunter's Tropical Medicine and Emerging Infectious Disease (ninth ed.). London: W.B. Saunders. pp. 815–822.
- PMID 16014169.
- PMID 15246315.