Nematode

Source: Wikipedia, the free encyclopedia.

Nematode
Temporal range: Early Devonian–Recent[1] Possible Cambrian occurrence [2]
Caenorhabditis elegans,
a model species of roundworm
Scientific classification Edit this classification
Domain: Eukaryota
Kingdom: Animalia
Subkingdom: Eumetazoa
Clade: ParaHoxozoa
Clade: Bilateria
Clade: Nephrozoa
(unranked): Protostomia
Superphylum: Ecdysozoa
Clade: Nematoida
Phylum: Nematoda
Diesing, 1861
Classes

(see text)

Synonyms
  • Nematodes Burmeister, 1837
  • Nematoidea sensu stricto Cobb, 1919
  • Nemates Cobb, 1919
  • Nemata Cobb, 1919 emend.

The nematodes (

helminths) are the cause of soil-transmitted helminthiases
.

They are taxonomically classified along with

flatworms, nematodes have a tubular digestive system, with openings at both ends. Like tardigrades, they have a reduced number of Hox genes, but their sister phylum Nematomorpha has kept the ancestral protostome Hox genotype, which shows that the reduction has occurred within the nematode phylum.[5]

Nematode species can be difficult to distinguish from one another. Consequently, estimates of the number of nematode species are uncertain. A 2013 survey of animal biodiversity published in the mega journal Zootaxa puts this figure at over 25,000.[6][7] Estimates of the total number of extant species are subject to even greater variation. A widely referenced article published in 1993 estimated there may be over 1 million species of nematode.[8] A subsequent publication challenged this claim, estimating the figure to be at least 40,000 species.[9] Although the highest estimates (up to 100 million species) have since been deprecated, estimates supported by rarefaction curves,[10][11] together with the use of DNA barcoding[12] and the increasing acknowledgment of widespread cryptic species among nematodes,[13] have placed the figure closer to 1 million species.[14]

Nematodes have successfully adapted to nearly every ecosystem: from marine (salt) to fresh water, soils, from the polar regions to the tropics, as well as the highest to the lowest of elevations. They are ubiquitous in freshwater, marine, and terrestrial environments, where they often outnumber other animals in both individual and species counts, and are found in locations as diverse as mountains, deserts, and oceanic trenches. They are found in every part of the Earth's lithosphere,[15] even at great depths, 0.9–3.6 km (3,000–12,000 ft) below the surface of the Earth in gold mines in South Africa.[16][17][18][19][20] They represent 90% of all animals on the ocean floor.[21] In total, 4.4 × 1020 nematodes inhabit the Earth's topsoil, or approximately 60 billion for each human, with the highest densities observed in tundra and boreal forests.[22] Their numerical dominance, often exceeding a million individuals per square meter and accounting for about 80% of all individual animals on Earth, their diversity of lifecycles, and their presence at various trophic levels point to an important role in many ecosystems.[22][23] They have been shown to play crucial roles in polar ecosystems.[24][25] The roughly 2,271 

genera are placed in 256 families.[26]
The many parasitic forms include
parasites of vertebrates; about 35 nematode species occur in humans.[26]

Nathan Cobb, a nematologist, described the ubiquity of nematodes on Earth thus:

In short, if all the matter in the universe except the nematodes were swept away, our world would still be dimly recognizable, and if, as disembodied spirits, we could then investigate it, we should find its mountains, hills, vales, rivers, lakes, and oceans represented by a film of nematodes. The location of towns would be decipherable since, for every massing of human beings, there would be a corresponding massing of certain nematodes. Trees would still stand in ghostly rows representing our streets and highways. The location of the various plants and animals would still be decipherable, and, had we sufficient knowledge, in many cases even their species could be determined by an examination of their erstwhile nematode parasites.[27](p 472)

Etymology

The word nematode comes from the Modern Latin compound of nemat- "thread" (from Greek nema, genitive nematos "thread," from stem of nein "to spin"; see needle) + -odes "like, of the nature of" (see -oid).

Taxonomy and systematics

Eophasma jurasicum, a fossilized nematode
Caenorhabditis elegans
Rhabditia
Nippostrongylus brasiliensis
Unidentified Anisakidae (Ascaridina: Ascaridoidea)
Oxyuridae Threadworm
Spiruridae Dirofilaria immitis
Nematode Steinernema feltiae with size comparison 1 EURO coin
Nematode Steinernema Feltiae with size comparison of 1 EURO coin

History

In 1758, Linnaeus described some nematode genera (e.g., Ascaris), then included in the Vermes.

The name of the group Nematoda, informally called "nematodes", came from

Nematoidea, originally defined by Karl Rudolphi (1808),[28] from Ancient Greek νῆμα (nêma, nêmatos, 'thread') and -ειδἠς (-eidēs, 'species'). It was treated as family Nematodes by Burmeister (1837).[28]

At its origin, the "Nematoidea" erroneously included Nematodes and

Cestoidea, it formed the obsolete group Entozoa,[29] created by Rudolphi (1808).[30] They were also classed along with Acanthocephala in the obsolete phylum Nemathelminthes
by Gegenbaur (1859).

In 1861,

Vejdovsky when he named a group to contain the horsehair worms the order Nematomorpha. In 1919, Nathan Cobb proposed that nematodes should be recognized alone as a phylum.[31]
He argued they should be called "nema" in English rather than "nematodes" and defined the taxon Nemates (later emended as Nemata, Latin plural of nema), listing Nematoidea sensu restricto as a synonym.

However, in 1910, Grobben proposed the phylum Aschelminthes and the nematodes were included as class Nematoda along with class Rotifera, class Gastrotricha, class Kinorhyncha, class Priapulida, and class Nematomorpha (The phylum was later revived and modified by Libbie Henrietta Hyman in 1951 as Pseudoceolomata, but remained similar). In 1932, Potts elevated the class Nematoda to the level of phylum, leaving the name the same. Despite Potts' classification being equivalent to Cobbs', both names have been used (and are still used today) and Nematode became a popular term in zoological science.[32]

Since Cobb was the first to include nematodes in a particular phylum separated from Nematomorpha, some researchers consider the valid taxon name to be Nemates or Nemata, rather than Nematoda,[33] because of the zoological rule that gives priority to the first used term in case of synonyms.

Phylogeny

The

superphylum.[34]

For an up-to-date view (as of 2022), see Phylogenomic Analysis of the Phylum Nematoda: Conflicts and Congruences With Morphology, 18S rRNA, and Mitogenomes.

Nematode systematics

Due to the lack of knowledge regarding many nematodes, their systematics is contentious. An early and influential classification was proposed by Chitwood and Chitwood

phasmids
, a pair of sensory organs located in the lateral posterior region, and this was used as the basis for this division. This scheme was adhered to in many later classifications, though the Adenophorea were not in a uniform group.

Initial studies of incomplete DNA sequences[38] suggested the existence of five clades:[39]

The Secernentea seem to be a natural group of close relatives, while the "Adenophorea" appear to be a

Diplogasteria may need to be united with the Rhabditia, while the Tylenchia might be paraphyletic with the Rhabditia.[40]

The understanding of roundworm systematics and

phylogeny
as of 2002 is summarised below:

Phylum Nematoda

Later work has suggested the presence of 12 clades.[41] The Secernentea—a group that includes virtually all major animal and plant 'nematode' parasites—apparently arose from within the Adenophorea.

In 2019, a study identified one conserved signature indel (CSI) found exclusively in members of the phylum Nematoda through comparative genetic analyses.[42] The CSI consists of a single amino acid insertion within a conserved region of a Na(+)/H(+) exchange regulatory factor protein NRFL-1 and is a molecular marker that distinguishes the phylum from other species.[42]

A major effort by a collaborative wiki called 959 Nematode Genomes is underway to improve the systematics of this phylum.[43]

An analysis of the mitochondrial DNA suggests that the following groupings are valid[44]

In 2022 a new classification of the entire phylum Nematoda was presented by M. Hodda. It was based on current molecular, developmental and morphological evidence.[45] Under this classification, the following classes and subclasses are presented:

Fossil record

Nematode eggs from the

palaeolake in present-day São Paulo with a diverse fossil assemblage of birds, fish, and arthropods that lent itself to fostering high nematode diversity.[46]

Anatomy

Internal anatomy of a male C. elegans nematode

Nematodes are very small, slender worms: typically about 5 to 100 μm thick, and 0.1 to 2.5 mm long.[47] The smallest nematodes are microscopic, while free-living species can reach as much as 5 cm (2 in), and some parasitic species are larger still, reaching over 1 m (3 ft) in length.[48]: 271  The body is often ornamented with ridges, rings, bristles, or other distinctive structures.[49]

The head of a nematode is relatively distinct. Whereas the rest of the body is bilaterally symmetrical, the head is radially symmetrical, with sensory bristles and, in many cases, solid 'head-shields' radiating outwards around the mouth. The mouth has either three or six lips, which often bear a series of teeth on their inner edges. An adhesive 'caudal gland' is often found at the tip of the tail.[50]

The epidermis is either a syncytium or a single layer of cells, and is covered by a thick collagenous cuticle. The cuticle is often of a complex structure and may have two or three distinct layers. Underneath the epidermis lies a layer of longitudinal muscle cells. The relatively rigid cuticle works with the muscles to create a hydroskeleton, as nematodes lack circumferential muscles. Projections run from the inner surface of muscle cells towards the nerve cords; this is a unique arrangement in the animal kingdom, in which nerve cells normally extend fibers into the muscles rather than vice versa.[50]

Digestive system

The oral cavity is lined with cuticle, which is often strengthened with structures, such as ridges, especially in carnivorous species, which may bear a number of teeth. The mouth often includes a sharp stylet, which the animal can thrust into its prey. In some species, the stylet is hollow and can be used to suck liquids from plants or animals.[50]

The oral cavity opens into a muscular, sucking pharynx, also lined with cuticle. Digestive glands are found in this region of the gut, producing enzymes that start to break down the food. In stylet-bearing species, these may even be injected into the prey.[50]

No

intestine that forms the main length of the gut. This produces further enzymes, and also absorbs nutrients through its single-cell-thick lining. The last portion of the intestine is lined by cuticle, forming a rectum, which expels waste through the bunghole just below and in front of the tip of the tail. The movement of food through the digestive system is the result of the body movements of the worm. The intestine has valves or sphincters at either end to help control the movement of food through the body.[50]

Excretory system

Nitrogenous waste is excreted in the form of ammonia through the body wall, and is not associated with any specific organs. However, the structures for excreting salt to maintain osmoregulation are typically more complex.[50]

In many marine nematodes, one or two unicellular 'renette glands' excrete salt through a pore on the underside of the animal, close to the pharynx. In most other nematodes, these specialized cells have been replaced by an organ consisting of two parallel ducts connected by a single transverse duct. This transverse duct opens into a common canal that runs to the excretory pore.[50]

Nervous system

At the anterior end of the animal a dense, circular nerve ring which serves as the brain surrounds the pharynx.[50] From this ring six labial papillary nerve cords extend anteriorly, while six nerve cords; a large ventral, a smaller dorsal and two pairs of sublateral cords extend posteriorly.[51] Each nerve lies within a cord of connective tissue lying beneath the cuticle and between the muscle cells. The ventral nerve is the largest, and has a double structure forward of the excretory pore. The dorsal nerve is responsible for motor control, while the lateral nerves are sensory, and the ventral combines both functions.[50]

The nervous system is also the only place in the nematode body that contains

cilia, which are all nonmotile and with a sensory function.[52][53]

The bodies of nematodes are covered in numerous sensory bristles and papillae that together provide a sense of touch. Behind the sensory bristles on the head lie two small pits, or 'amphids'. These are well supplied with nerve cells and are probably chemoreception organs. A few aquatic nematodes possess what appear to be pigmented eye-spots, but whether or not these are actually sensory in nature is unclear.[50]

Reproduction

spicule, used for copulation, bar = 100 μm[54]

Most nematode species are

seminal vesicle and then during intercourse into a glandular and muscular ejaculatory duct associated with the vas deferens and cloaca. In females, the ovaries each open into an oviduct (in hermaphrodites, the eggs enter a spermatheca first) and then a glandular uterus. The uteri both open into a common vulva/vagina, usually located in the middle of the morphologically ventral surface.[50]

Reproduction is usually sexual, though hermaphrodites are capable of self-fertilization. Males are usually smaller than females or hermaphrodites (often much smaller) and often have a characteristically bent or fan-shaped tail. During

G-actin
.

Eggs may be

ovoviviparous. The eggs are protected by an outer shell, secreted by the uterus. In free-living roundworms, the eggs hatch into larvae, which appear essentially identical to the adults, except for an underdeveloped reproductive system; in parasitic roundworms, the lifecycle is often much more complicated.[50] The structure of the eggshell is complicated and includes several layers; a detailed anatomical and terminological framework has been proposed for these layers in 2023.[55]

Nematodes as a whole possess a wide range of modes of reproduction.

endotokia matricida: intrauterine birth causing maternal death.[57] Some nematodes are hermaphroditic, and keep their self-fertilized eggs inside the uterus until they hatch. The juvenile nematodes then ingest the parent nematode. This process is significantly promoted in environments with a low food supply.[57]

The nematode model species C. elegans,

Meloidogyne (root-knot nematodes) exhibits a range of reproductive modes, including sexual reproduction, facultative sexuality (in which most, but not all, generations reproduce asexually), and both meiotic and mitotic parthenogenesis
.

The genus Mesorhabditis exhibits an unusual form of parthenogenesis, in which sperm-producing males copulate with females, but the sperm do not fuse with the ovum. Contact with the sperm is essential for the ovum to begin dividing, but because no fusion of the cells occurs, the male contributes no genetic material to the offspring, which are essentially clones of the female.[50]

Aging

The nematode Caenorhabditis elegans is often used as a model organism for studying aging at the molecular level. For example, in C. elegans aging negatively impacts DNA repair, and mutants of C. elegans that are long lived were shown to have increased DNA repair capability.[59] These findings suggest a genetically determined correlation between DNA repair capacity and lifespan.[59] In female C. elegans, germline processes that control DNA repair and formation of chromosomal crossovers during meiosis were shown to progressively deteriorate with age.[60]

Free-living species

Different free-living species feed on materials as varied as

fungi, small animals, fecal matter, dead organisms, and living tissues. Free-living marine nematodes are important and abundant members of the meiobenthos. They play an important role in the decomposition process, aid in recycling of nutrients in marine environments, and are sensitive to changes in the environment caused by pollution. One roundworm of note, C. elegans, lives in the soil and has found much use as a model organism
. C. elegans has had its entire genome sequenced, the developmental fate of every cell determined, and every neuron mapped.

Parasitic species

primates

Nematodes that commonly parasitise humans include

whipworms (Trichuris trichiura). The species Trichinella spiralis, commonly known as the 'trichina worm', occurs in rats, pigs, bears, and humans, and is responsible for the disease trichinosis. Baylisascaris usually infests wild animals, but can be deadly to humans, as well. Dirofilaria immitis is known for causing heartworm disease by inhabiting the hearts, arteries, and lungs of dogs and some cats. Haemonchus contortus is one of the most abundant infectious agents in sheep around the world, causing great economic damage to sheep. In contrast, entomopathogenic nematodes
parasitize insects and are mostly considered beneficial by humans, but some attack beneficial insects.

One form of nematode is entirely dependent upon fig wasps, which are the sole source of fig fertilization. They prey upon the wasps, riding them from the ripe fig of the wasp's birth to the fig flower of its death, where they kill the wasp, and their offspring await the birth of the next generation of wasps as the fig ripens.

electron micrograph of soybean cyst nematode
(Heterodera sp.) and egg

A parasitic tetradonematid nematode discovered in 2005,

frugivorous birds to confuse the infected ants for berries, and eat them. Parasite eggs passed in the bird's feces are subsequently collected by foraging C. atratus and are fed to their larvae, thus completing the lifecycle of M. neotropicum.[61]

Similarly, multiple varieties of nematodes have been found in the abdominal cavities of the primitively social sweat bee, Lasioglossum zephyrus. Inside the female body, the nematode hinders ovarian development and renders the bee less active, thus less effective in pollen collection.[62]

Agriculture and horticulture

Depending on its species, a nematode may be beneficial or detrimental to plant health. From agricultural and

vectors spreading plant viruses between crop plants.[63]
Predatory nematodes include
root-knot nematodes), Nacobbus, Pratylenchus (lesion nematodes), Trichodorus, and Xiphinema (dagger nematodes). Several phytoparasitic nematode species cause histological damages to roots, including the formation of visible galls (e.g. by root-knot nematodes), which are useful characters for their diagnostic in the field. Some nematode species transmit plant viruses through their feeding activity on roots. One of them is Xiphinema index, vector of grapevine fanleaf virus, an important disease of grapes, another one is Xiphinema diversicaudatum, vector of arabis mosaic virus. Other nematodes attack bark and forest trees. The most important representative of this group is Bursaphelenchus xylophilus, the pine wood nematode, present in Asia and America and recently discovered in Europe. This nematode is transmitted from tree to tree by sawyer beetles (Monochamus).[68]

Greenhouse growers use

beneficial nematodes to control fungus gnats, the nematodes enter the larva of the gnats by way of their anus, mouth, and spiracles (breathing pores) and then release a bacteria which kills the gnat larvae; commonly used nematode species to control pests on greenhouse crops include Steinernema feltiae for fungus gnats and western flower thrips, Steinernema carpocapsae used to control shore flies, Steinernema kraussei for control of black vine weevils, and Heterorhabditis bacteriophora to control beetle larvae.[69]

Rotations of plants with nematode-resistant species or varieties is one means of managing parasitic nematode infestations. For example, planting

corn, sugar beet, potato, and tomato crops without harming beneficial nematodes in the soil.[71] Soil steaming
is an efficient method to kill nematodes before planting a crop, but indiscriminately eliminates both harmful and beneficial soil fauna.

The golden nematode

Chinese mustard Brassica juncea green manure or seed meal in the soil.[72]

Epidemiology

Disability-adjusted life year for intestinal nematode infections per 100,000 in 2002.
    <  25
  25–50
  50–75
  75–100
  100–120
  120–140
  140–160
  160–180
  180–200
  200–220
  220–240
    >  240
  no data
Heligmosomoides bakeri

A number of intestinal nematodes cause diseases affecting human beings, including

hookworm disease. Filarial nematodes cause filariases. Furthermore, studies have shown that parasitic nematodes infect American eels causing damage to the eel's swim bladder,[73] dairy animals like cattle and buffalo,[74] and all species of sheep.[75]

Gastrointestinal nematode infections in humans are common, with approximately 50% of the global population being affected. Developing countries are most heavily impacted, in part due to lack of access to medical care.[76]

Soil ecosystems

About 90% of nematodes reside in the top 15 cm (6") of soil. Nematodes do not decompose organic matter, but, instead, are parasitic and free-living organisms that feed on living material. Nematodes can effectively regulate bacterial population and community composition—they may eat up to 5,000 bacteria per minute. Also, nematodes can play an important role in the nitrogen cycle by way of nitrogen mineralization.[47]

One group of carnivorous fungi, the nematophagous fungi, are predators of soil nematodes.[77] They set enticements for the nematodes in the form of lassos or adhesive structures.[78][79][80]

Survivability

Nematode worms (C. elegans), part of an ongoing research project conducted on the 2003 Space Shuttle Columbia mission STS-107, survived the re-entry breakup. It is believed to be the first known life form to survive a virtually unprotected atmospheric descent to Earth's surface.[81][82] In a research project published in 2012, it was found that the Antarctic Nematodes (P. davidi) was able to withstand intracellular freezing depending on how well it was fed.[83] In 2023 it was reported that an individual of Panagrolaimus kolymaensis had been revived after 46,000 years in Siberian permafrost.[84]

See also

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