CDON
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| Location (UCSC) | Chr 11: 125.96 – 126.06 Mb | Chr 9: 35.42 – 35.51 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the CDON gene.[5][6]
CDON and
Structure and function
Cell adhesion molecule-related/down-regulated by oncogenes (CDON) is a conserved transmembrane
Clinical significance
CDON mutations are thought to diminish
Gene knockdown studies
CDON knockdown using morpholinos in zebra fish altered the eye development, CDON was shown important in restraining the size of the optic stalk and ventral retina in chick embryos.[13] Additionally, double CDON knock out mice display optic nerve hypoplasia (ONH), a prominent feature of septo-optic dysplasia (SOD), the same phenotype shown by treating mice prenatally with ethanol.[14] CDON−/− animals also show cardiac dysfunction with increased fibrosis, those cardiac effects are mediated through hyperactivation of WNT/β-catenin signaling.[15]
Interactions
CDON has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000064309 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038119 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9214393.
- ^ a b "Entrez Gene: CDON Cdon homolog (mouse)".
- PMID 22326621.
- PMID 9786951.
- PMID 26256768.
- PMID 20519495.
- PMID 25117422.
- PMID 21802063.
- ^ PMID 23071453.
- PMID 27935818.
- PMID 28154134.
- PMID 12634428.
- PMID 11782431.
Further reading
- Wegorzewska M, Krauss RS, Kang JS (May 2003). "Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD". Molecular Carcinogenesis. 37 (1): 1–4. S2CID 46652847.
- Cole F, Krauss RS (March 2003). "Microform holoprosencephaly in mice that lack the Ig superfamily member Cdon". Current Biology. 13 (5): 411–5. S2CID 14868560.
External links
- Human CDON genome location and CDON gene details page in the UCSC Genome Browser.
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