CXorf36
| DIPK2B | ||||||
|---|---|---|---|---|---|---|
| Identifiers | ||||||
Ensembl | ||||||
| UniProt | ||||||
| RefSeq (mRNA) | ||||||
| RefSeq (protein) | ||||||
| Location (UCSC) | Chr X: 45.15 – 45.2 Mb | Chr X: 18.28 – 18.33 Mb | ||||
| PubMed search | [3] | [4] | ||||
| View/Edit Human | View/Edit Mouse |
Chromosome X open reading frame 36 (CXorf36) is a gene that in humans encodes a protein “hypothetical protein LOC79742”. This protein has a function that is not currently very well understood.[5][6] Other known aliases are “FLJ14103, DKFZp313K0825, FLJ55198, PRO3743, FLJ55198, hCG1981635, bA435K1.1,” and “4930578C19Rik.”[7]
Gene
The CXorf36 gene is located at Xp11.3.
The genomic DNA is 52,529 base pairs long,[5] while the longest mRNA that it produces is 4,735 bases long.
Gene Neighborhood
CXorf36 is closely surrounded by the following genes on chromosome X:[5]
- DUSP21
- KDM6A
- MIR222
- TBX20
CXorf36 is also surrounded by two other genes on chromosome X that have been implicated in
Protein
The longest
Domains
The CXorf36 gene protein product contains a region of low complexity from position 16 to position 40.[12]
Post-translational Modification
The CXorf36 protein is predicted to undergo phosphorylation at several serines, threonines, and tyrosines throughout the structure.[13] However, many of these sites are predicted at serines. There is also a predicted N-linked glycosylation site at position 100 on the protein product.[14]
Expression
CXorf36 is shown to be expressed ubiquitously at low levels in various tissues throughout the body. It is expressed highly in the ciliary ganglion, ovary, and uterus corpus. However, highest expression is seen in the trigeminal ganglion tissue.[15]
Conservation
CXorf36 has one
- Pongo abelii
- Macaca mulatta
- Callithrix jacchus
- Canis familiaris
- Ailuropoda melanoleuca
- Equus caballus
- Oryctolagus cuniculus
- Mus musculus
- Rattus norvegicus
- Monodelphis domestica
- Ornithorhynchus anatinus
- Taeniopygia guttata
- Gallus gallus
- Danio rerio
- Bos taurus
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000147113 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037358 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "Entrez Gene: CXorf36". Retrieved 2011-04-28.
- PMID 11944989.
- ^ "GeneCards: CXorf36 Gene". Retrieved 2011-04-28.
- ^ "NCBI AceView: CXorf36". Retrieved 2011-04-28.
- PMID 19377476.
- ^ "NCBI Protein: hypothetical protein LOC79742 isoform 1". Retrieved May 10, 2011.
- ^ "SDSC Biology Workbench". Retrieved May 10, 2011.[permanent dead link]
- ^ "MyHits Dotlet". Retrieved May 10, 2011.
- ^ "DTU Center for Biological Sciences, NetPhos". Retrieved May 10, 2011.
- ^ "DTU Center for Biological Sciences, NetNGlyc". Retrieved May 10, 2011.
- ^ "NCBI GEO Profiles: CXorf36". Retrieved May 10, 2011.
- ^ "KEGG: C3orf58". Retrieved May 10, 2011.
- ^ "NCBI BLAST". Retrieved May 9, 2011.
External links
- Human CXorf36 genome location and CXorf36 gene details page in the UCSC Genome Browser.
Further reading
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. PMID 15342556.
- Tarpey PS, Smith R, Pleasance E, et al. (2009). "A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation". Nat. Genet. 41 (5): 535–43. PMID 19377476.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039.
- Thiselton DL, McDowall J, Brandau O, et al. (2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders". Genomics. 79 (4): 560–72. PMID 11944989.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. PMID 12975309.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. PMID 16344560.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. PMID 11181995.
- Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. PMID 18029348.
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