Caldoramide
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3D model (
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PubChem CID
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Properties | |
C37H59N5O6 | |
Molar mass | 669.908 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Caldoramide is a pentapeptidecytotoxic effects on cancer cells and has been the subject of extensive oncological research.[3] It is structurally analogous to belamide A and dolastatin 15. Its appearance is that of a powdery, white, substance.[3]
Structure
The N-terminus for Caldoramide is N,N-dimethylvaline which is attached to a valine which is attached to an N-Me-valine connected to an N-Me-isoleucine which is attached to the C-terminus. The molecule can also be written as N,N-diMe-Val-Val-N-Me-Val-N-Me-Ile-3-O-Me-4-benzylpyrrolinone.[3]
Extraction
Freeze-dried samples of Caldora penicillata had
n-BuOH and H2O and then fractions were taken based on solubility in either EtOAc or BuOH. Caldoramide was extracted from the BuOH soluble fraction.[3]
Pharmacological activity
Caldoramide has been found to be cytotoxic against
HCT116 colorectal cancer cell lines.[3]