Caspase recruitment domain-containing protein 8
Caspase recruitment domain-containing protein 8 is a protein that in humans is encoded by the CARD8 gene.[3][4][5]
Function
Caspase recruitment domain (CARD)-containing proteins, such as CARD8, are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NF-κB) in the context of apoptosis or inflammation, respectively.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000105483 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 10231032.
- PMID 11408476.
- ^ a b "Entrez Gene: CARD8 caspase recruitment domain family, member 8".
Further reading
- Fontalba A, Martinez-Taboada V, Gutierrez O, et al. (2007). "Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity". J. Immunol. 179 (7): 4867–73. PMID 17878386.
- Franke A, Rosenstiel P, Balschun T, et al. (2007). "No association between the TUCAN (CARD8) Cys10Stop mutation and inflammatory bowel disease in a large retrospective German and a clinically well-characterized Norwegian sample". Gastroenterology. 132 (5): 2080–1. PMID 17484912.
- McGovern DP, Butler H, Ahmad T, et al. (2006). "TUCAN (CARD8) genetic variants and inflammatory bowel disease". Gastroenterology. 131 (4): 1190–6. PMID 17030188.
- Checinska A, Giaccone G, Hoogeland BS, et al. (2006). "TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells". BMC Cancer. 6: 166. PMID 16796750.
- Agostini L, Martinon F, Burns K, et al. (2004). "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder". Immunity. 20 (3): 319–25. PMID 15030775.
- Stilo R, Leonardi A, Formisano L, et al. (2002). "TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation". FEBS Lett. 521 (1–3): 165–9. S2CID 21781671.
- Zhang H, Fu W (2002). "NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation". Int. J. Oncol. 20 (5): 1035–40. PMID 11956601.
- Razmara M, Srinivasula SM, Wang L, et al. (2002). "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis". J. Biol. Chem. 277 (16): 13952–8. PMID 11821383.
- Bouchier-Hayes L, Conroy H, Egan H, et al. (2001). "CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways". J. Biol. Chem. 276 (47): 44069–77. PMID 11551959.
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