Cross dehydrogenative coupling
Cross dehydrogenative coupling (also known as CDC reaction), coined by prof. Chao-Jun Li of McGill University,[1][2][3][4] is a type of coupling reaction allowing the construction of a carbon–carbon bond[5] or C-Heteroatom bond[6] directly from C-H bonds in the presence of an oxidant, leading to the thermodynamically unfavorable formal removal of a H2 molecule. As such, CDC are couplings belonging to the C-H activation strategy.
The key to the CDC coupling is eliminating the need for substrate prefunctionalization. Therefore, the CDC reaction has the advantages of high efficiency,
heterocycles have also been achieved via CDC.[11]