Cyclic AMP receptors
| Slime mold cyclic AMP receptor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Dicty_CAR | ||||||||
| Pfam | PF05462 | ||||||||
| Pfam clan | CL0192 | ||||||||
| InterPro | IPR000848 | ||||||||
| PROSITE | PDOC00691 | ||||||||
| CDD | cd14940 | ||||||||
| |||||||||
Cyclic AMP receptors from slime molds are a distinct family of
G-protein coupled receptors
. These receptors control development in
Dictyostelium discoideum.
In D. discoideum, the
cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes.[1][2][3]
The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However, while a similar 3D framework has been proposed to account for this, there is no significant sequence similarity between these families: the cAMP receptors thus bear their own unique '7TM' signature.
See also
References