DEP domain
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) | |||||||||
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Identifiers | |||||||||
Symbol | DEP | ||||||||
Pfam | PF00610 | ||||||||
InterPro | IPR000591 | ||||||||
CDD | cd04371 | ||||||||
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In molecular biology, the DEP domain (Dishevelled, Egl-10 and Pleckstrin domain) is a globular
signalling pathways. It was named after the three proteins
it was initially found in:
- signalling.
- Egl-10, which regulates G-protein signalling in the central nervous system in RGS9.[1]
- flanking the DEP domain.
G protein-coupled signaling pathways.[2][3] Nuclear magnetic resonance spectroscopy has revealed that the DEP domain comprises a three-helix bundle, a beta-hairpin 'arm' composed of two beta-strands and two short beta-strands in the C-terminal region.[3]