NACHT domain

The NACHT domain is an evolutionarily conserved

The NACHT domain consists of seven distinct conserved motifs, including the ATP/GTPase specific P-loop, the Mg²⁺-binding site (Walker A and B motifs, respectively) and five more specific motifs. The unique features of the NACHT domain include the prevalence of 'tiny' residues (glycine, alanine or serine) directly C-terminal of the Mg²⁺-coordinating aspartate in the Walker B motif, in place of a second acidic residue prevalent in other NTPases. A second acidic residue is typically found in the NACHT-containing proteins two positions downstream. Furthermore, the distal motif VII contains a conserved pattern of polar, aromatic and hydrophobic residues that is not seen in any other NTPase family.^[1]

Examples

Human proteins containing this domain include:

• CIITA
• NAIP
• NLRC3, NLRC4, NLRC5
• NLRP1, NLRP2, NLRP3, NLRP4, NLRP5, NLRP6, NLRP7, NLRP8, NLRP9, NLRP10, NLRP11, NLRP12, NLRP13, NLRP14, NLRX1
• NOD1, NOD2
• NWD1
• TEP1

References

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