DHX29
| DHX29 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function |
| ||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 5: 55.26 – 55.31 Mb | Chr 13: 113.06 – 113.11 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
DExH-box helicase 29 (DHX29) is a 155 kDa protein that in humans is encoded by the DHX29 gene.[5]
Function
This gene encodes a member of the
codon selection.[6] This protein may also play a role in sensing virally derived cytosolic nucleic acids.[7] Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells.[8]
Interactions
DHX29 has been shown to
See also
- Eukaryotic translation
- DExD/H box proteins
- Ded1/DDX3
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000067248 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042426 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: DExH-box helicase 29".
- PMID 19109895.
- PMID 24821782.
- PMID 20018725.
- PMID 23706745.
- PMID 24185006.
- PMID 27733651.
- PMID 26344199.
Further reading
- Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (September 2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. PMID 20877624.
- Dhote V, Sweeney TR, Kim N, Hellen CU, Pestova TV (November 2012). "Roles of individual domains in the function of DHX29, an essential factor required for translation of structured mammalian mRNAs". Proceedings of the National Academy of Sciences of the United States of America. 109 (46): E3150-9. PMID 23047696.
- Pisareva VP, Pisarev AV (May 2016). "DHX29 reduces leaky scanning through an upstream AUG codon regardless of its nucleotide context". Nucleic Acids Research. 44 (9): 4252–65. PMID 27067542.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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