DNA walker
A DNA walker is a class of nucleic acid nanomachines where a nucleic acid "walker" is able to move along a nucleic acid "track". The concept of a DNA walker was first defined and named by John H. Reif in 2003.[1] A nonautonomous DNA walker requires external changes for each step, whereas an autonomous DNA walker progresses without any external changes. Various nonautonomous DNA walkers were developed, for example Shin [2] controlled the motion of DNA walker by using 'control strands' which needed to be manually added in a specific order according to the template's sequence in order to get the desired path of motion. In 2004 the first autonomous DNA walker, which did not require external changes for each step, was experimentally demonstrated by the Reif group. [3]
DNA walkers have functional properties such as a range of motion extending from linear to 2 and 3-dimensional, the ability to pick up and drop off molecular cargo,[4] performing DNA-templated synthesis, and increased velocity of motion. DNA walkers have potential applications ranging from nanomedicine to nanorobotics.[5][6][7] Many different fuel options have been studied including DNA hybridization, hydrolysis of DNA or ATP, and light.[8][9] The DNA walker's function is similar to that of the proteins dynein and kinesin.[5]
Role in DNA nanotechnology
Finding a suitable nanoscale motor capable of autonomous, unidirectional, linear motion is considered important to the development of
Applications
The applications of DNA walkers include
See also
References
- S2CID 6200417.
- PMID 15339155.
- PMID 15372637.
- PMID 28912216.
- ^ PMID 19739195.
- ^ PMID 25498478.
- ^ PMID 24770565.
- PMID 22298502.
- S2CID 85446523.
- .
- PMID 20463735.
- PMID 20463734.
- PMID 20935654.
- PMID 26619152.
- PMID 29632399.
- ISBN 9781439863237.
- ^ a b "Nano-walkers take speedy leap forward with first rolling DNA-based motor". phys.org. Retrieved 2015-12-04.
- ^ "Chapter 18 : DNA Nano Robotics – NanoTechnology Journal & Publications". NanoTechnology Journal & Publications. Archived from the original on 2015-12-08. Retrieved 2015-12-04.
- PMID 29760489.