Dose dumping

Dose dumping is a phenomenon of

Dose dumping is most commonly seen in drugs taken by mouth and digested in the gastrointestinal tract. Around the same time patients take their medication, they can also ingest other substances like fatty meals or alcohol that increase drug delivery. The substances may act on the drug's capsule to speed up drug release, or they may stimulate the body's absorptive surfaces to increase the rate of drug uptake.

Dose dumping is a disadvantage found in extended release dosage form.

In general,

It is by definition an unintended rapid release in large amounts of a modified-release dosage due to a co-ingestion with ethanol.^[3]

Some interactions between alcohol, biological factors and the presentation of the drug can influence the apparition of AIDD by:

• Disrupting the drug release mechanism.^[4]
• Prolonging
  gastric emptying.^[5]
• Changing the amount of gastric acid.
• Enhancing the drug absorption due to an increase in solubility.^[6]
• Increasing the wetting effect and therefore speeding up the drug release.^[7]
• A decrease in swelling capacity by the matrix, accelerating the release.^[8]

Food-induced dose dumping (FIDD)

Food intake produces dynamic changes in digestion and

Some of the mechanisms involved in FIDD are:[10]^[11]

• Changes in composition and volumes of luminal fluid.
• Modification in gastrointestinal motility and consequently transit time of the stomach.
• Variation in concentration of bile salts and lipids.
• Loss of drug's matrix integrity due to changes in pH, fat and bile.

References

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