EPH receptor B2

EPHB2
	Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; transmembrane-ephrin receptor activity; kinase activity; protein binding; identical protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; signaling receptor binding; ATP binding; axon guidance receptor activity; ephrin receptor activity; amyloid-beta binding; signaling receptor activity; protein-containing complex binding;
Cellular component	integral component of membrane; cytosol; cell projection; membrane; integral component of plasma membrane; extracellular region; axon; neuronal cell body; dendrite; nucleus; plasma membrane; neuron projection; receptor complex; postsynapse; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane;
Biological process	positive regulation of synapse assembly; roof of mouth development; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; optic nerve morphogenesis; ephrin receptor signaling pathway; learning; commissural neuron axon guidance; nervous system development; multicellular organism development; regulation of axonogenesis; dendritic spine development; dendritic spine morphogenesis; negative regulation of axonogenesis; protein phosphorylation; positive regulation of long-term neuronal synaptic plasticity; regulation of body fluid levels; inner ear morphogenesis; angiogenesis; cell morphogenesis; animal organ morphogenesis; regulation of neuronal synaptic plasticity; urogenital system development; peptidyl-tyrosine phosphorylation; corpus callosum development; central nervous system projection neuron axonogenesis; axonal fasciculation; camera-type eye morphogenesis; retinal ganglion cell axon guidance; axon guidance; trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission; negative regulation of protein phosphorylation; learning or memory; positive regulation of gene expression; positive regulation of synaptic plasticity; negative regulation of Ras protein signal transduction; regulation of synapse assembly; negative regulation of ERK1 and ERK2 cascade; postsynaptic membrane assembly; neuron projection retraction; positive regulation of long-term synaptic potentiation; positive regulation of protein localization to plasma membrane; negative regulation of NMDA glutamate receptor activity; positive regulation of NMDA glutamate receptor activity;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000133216


ENSMUSG00000028664

UniProt


P29323


P54763

RefSeq (mRNA)


NM_001309192 NM_001309193 NM_004442 NM_017449


NM_001290753 NM_010142

RefSeq (protein)


NP_001296121 NP_001296122 NP_004433 NP_059145


NP_001277682 NP_034272

Location (UCSC)

Chr 1: 22.71 – 22.92 Mb

Chr 4: 136.37 – 136.56 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene.^[5]

Function

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.^[6]

Animal studies

EphB2 is part of the

animal model of Alzheimer's disease.^[7]

A

pigeons.^[8]

Interactions

EPH receptor B2 has been shown to

interact

with:

Abl gene^[9]

RAS p21 protein activator 1^[10]
Src^[11]^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133216 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028664 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
PMID 1648701
.

^ "Entrez Gene: EPHB2 EPH receptor B2".

PMID 21113149
.
"Protein provides Alzheimer's clue". NHS Choices. November 29, 2010. Archived from the original on 2011-05-18.

PMID 23371554
.
Carl Zimmer (February 4, 2013). "Pigeons Get a New Look". The New York Times.

PMID 11494128
.

PMID 9233798
.

PMID 9632142
.

PMID 10644995
.

v
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PDB gallery

1b4f: OLIGOMERIC STRUCTURE OF THE HUMAN EPHB2 RECEPTOR SAM DOMAIN

1f0m: MONOMERIC STRUCTURE OF THE HUMAN EPHB2 SAM (STERILE ALPHA MOTIF) DOMAIN

1jpa: Crystal Structure of unphosphorylated EphB2 receptor tyrosine kinase and juxtamembrane region

1kgy: Crystal Structure of the EphB2-ephrinB2 complex

1nuk: CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE EPHB2 RECEPTOR TYROSINE KINASE

1sgg: THE SOLUTION STRUCTURE OF SAM DOMAIN FROM THE RECEPTOR TYROSINE KINASE EPHB2, NMR, 10 STRUCTURES

1shw: EphB2 / EphrinA5 Complex Structure

2hen: Crystal Structure of the EphB2 Receptor Kinase domain in complex with ADP

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Retrieved from "https://en.wikipedia.org/w/index.php?title=EPH_receptor_B2&oldid=1081651462"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133216 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028664 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1648701-5] PMID 1648701
.

[6] "Entrez Gene: EPHB2 EPH receptor B2".

[pmid21113149-7] PMID 21113149
.
"Protein provides Alzheimer's clue". NHS Choices. November 29, 2010. Archived from the original on 2011-05-18.

[8] "Protein provides Alzheimer's clue". NHS Choices. November 29, 2010. Archived from the original on 2011-05-18.

[pmid23371554-8] PMID 23371554
.
Carl Zimmer (February 4, 2013). "Pigeons Get a New Look". The New York Times.

[10] Carl Zimmer (February 4, 2013). "Pigeons Get a New Look". The New York Times.

[pmid11494128-9] PMID 11494128
.

[pmid9233798-10] PMID 9233798
.

[pmid9632142-11] PMID 9632142
.

[pmid10644995-12] PMID 10644995
.

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