Edward Wild (neuroscientist)

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This article is about the British neurologist. For the American Civil War general, see
Institute of Neurology;
National Hospital for Neurology and NeurosurgeryThesisIdentification and evaluation of biomarkers for Huntington's disease (2009)Doctoral advisorSarah Tabrizi
Websiteedwild.com

Edward Wild, also known as Ed Wild, is a British

UCL Institute of Neurology and is an associate director of the UCL Huntington's Disease Centre.[3] He is also a consultant neurologist at the National Hospital for Neurology and Neurosurgery in London.[4]

Career

Wild studied medicine at

UCL Institute of Neurology, Queen Square, London,[7] during which he published research on biomarkers for Huntington's disease using magnetic resonance imaging measures of brain atrophy[8][9][10][11] and biochemical analysis of blood.[12][13] Wild and Tabrizi continue to work together at the UCL Huntington's Disease Centre.[14]

Wild and colleagues described a novel pathogenic pathway of immune activation in Huntington's[15][16] which later became the basis of clinical trials of immune-targeted therapies.[17] In 2015, he published the first successful detection and quantification of mutant huntingtin protein (the known cause of Huntington's) in human cerebrospinal fluid, using a novel 'single-molecule counting' immunoassay. This finding was noted as a 'research highlight' by Nature Reviews Neurology and won Wild the Huntington Study group 'Insight of the Year' award in 2015.[18][19][20] He has also published novel genetic causes of 'phenocopy' syndromes that mimic Huntington's disease.[21][22]

Wild's research since 2017 has focused on the potential of neurofilament light and mutant huntingtin protein

antisense oligonucleotide tominersen to lower mutant huntingtin production in HD,[26] and gave the first dose of the drug to a patient in 2015.[27][28][29]

He serves on the Medical Advisory Panel of the UK Huntington's Disease Association,[2] the Editorial Board of the Journal of Huntington's Disease,[30] the Association of British Neurologists Neurogenetics Advisory Panel,[31] and the Translational Neurology Panel of the European Academy of Neurology.[32] He is a member of the Executive Committee of the European Huntington's Disease Network[33] and Co-lead facilitator of the Network’s Biomarkers Working Group.[34] He is a founder member of the advisory panel to the UK All-Party Parliamentary Group on Huntington's disease.[35][36]

He was promoted to professor of neurology in October 2020, in the UCL Faculty of Brain Sciences.[37] As of September 2022, Wild has authored 7 book chapters[3] and 150 peer-reviewed publications with over 12,000 citations.[38]

Public engagement work

In 2010, with Jeff Carroll, Wild founded HDBuzz, an online source of accessible news about Huntington's disease research,[39][40] that has received awards from patient advocacy groups.[41] He said he helped establish HDBuzz to provide tempered research news to counter the hype of medical press releases about HD.[42] He has commented that common online opinions that people with Huntington's disease should not be allowed to have children "borders on historical eugenics-type thinking".[43] He has described Huntington's as "the most curable incurable brain disorder" because of the possibility of targeting treatments to its known genetic cause.[44][45]

Wild appeared in the documentary feature film The Inheritance[46][47] and was a judge for the 2015 British Library / Europe PubMed Central 'Access to Understanding' contest for science writers.[48] He has appeared on the BBC Radio Naked Scientists programme.[49] In July 2016, he appeared on BBC Radio 4's Woman's Hour programme talking about Huntington's disease with Jenni Murray.[50] In December 2017, he appeared on RTE Radio 1 talking about Huntington's disease treatments.[51] In 2020, he appeared in the Ken Burns PBS documentary The Gene: An Intimate History.[52][53]

In 2021, he wrote the afterword of Patient 1,[54] a book by Charlotte Raven about her experiences with Huntington's disease, including her participation on the trial of the experimental drug tominersen.[29] Wild is Raven's doctor and injected her with the first dose of tominersen on the Gen-Peak trial.[29]

Personal life

Wild lives in East London with his partner Joel. They have a cat and a chihuahua, Riley.[29]

Awards and honours

References

  1. PMID 28128771
    .
  2. ^ a b "HD Centre - People - Team Wild". UCL Queen Square Institute of Neurology. 17 October 2019. Retrieved 2 December 2021.
  3. ^ a b c "UCL Iris Profile – Prof. Edward Wild". Retrieved 2 December 2021.
  4. PMID 26911764
    .
  5. ^ "Christ's College Pieces Magazine". 27 July 2021.
  6. ^ Phillips, Helen (25 March 2009). "Déjà vu: Where fact meets fantasy". New Scientist. pp. 3, 5. Archived from the original on 13 April 2016. Retrieved 31 March 2016.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
  7. ^ Wild, Edward (June 2009). Identification and evaluation of biomarkers for Huntington's disease (PhD Thesis). UCL Discovery Institutional Document Repository (Doctoral). University College London.
  8. PMID 24126537
    .
  9. S2CID 33524701
    .
  10. S2CID 206239857
    .
  11. ISBN 978-3642008177
    .
  12. PMID 23485116
    .
  13. PMID 22996692
    .
  14. S2CID 221129777
    .
  15. PMID 18625748
    .
  16. PMID 17552550
    .
  17. ^ "A Clinical Study in Subjects With Huntington's Disease to Assess the Efficacy and Safety of Three Oral Doses of Laquinimod - Full Text View". ClinicalTrials.gov. Retrieved 2016-03-31.
  18. PMID 25844897
    .
  19. S2CID 38300571
    .
  20. ^ a b "Announcing HSG's 2015 Award Winners". Huntington Study Group. Archived from the original on 2021-11-26. Retrieved 2016-03-31.
  21. PMID 24363131
    .
  22. S2CID 3086383
    .
  23. ^ "Huntington's disease trial test is 'major advance'". BBC News. 8 June 2017.
  24. ^
    S2CID 206695500
    .
  25. PMID 33328328
    .
  26. S2CID 146811503
    .
  27. ^ Whipple, Tom. "Huntington's breakthrough offers hope to thousands". The Times. Retrieved 2 December 2021.
  28. ^ Devlin, Hannah (11 December 2017). "Excitement as trial shows Huntington's drug could slow progress of disease". the Guardian. Retrieved 2 December 2021.
  29. ^ a b c d Louise, Carpenter (30 October 2021). "Charlotte Raven: Huntington's disease is 'a burden that is almost impossible to bear'". The Times. Retrieved 2 December 2021.
  30. ^ "Journal of Huntington's Disease". IOS Press. Retrieved 2016-03-31.
  31. ^ "Association of British Neurologists Annual Report 2020-21" (PDF). Association of British Neurologists. Retrieved 2 December 2021.
  32. ^ "Neuroscience/Translational neurology". European Academy of Neurology.
  33. ^ "EHDN Structure – European Huntington's Disease Network". ehdn.org. Retrieved 2022-10-19.
  34. ^ "Biomarkers Working Group – European Huntington's Disease Network". EHDN. Retrieved 2 December 2021.
  35. ^ Harrison, Jacqueline (December 2013). The 'hidden no more' mass lobby June 2010 - using oral histories and cultural representations to explore the concealment of Huntington's disease. (Masters Thesis). University of Huddersfield Repository (masters).
  36. ^ "Massive Underestimation In The Prevalence Of Huntington's Disease In The UK Population". Science 2.0. 27 August 2014. Retrieved 2016-03-31.
  37. ^ "Promotions 2019-20 - Professors". UCL Human Resources. 29 June 2020.
  38. ^ "Dr Edward J Wild". Google Scholar Citations. Retrieved 2 November 2021.
  39. ISBN 978-0199370474
    .
  40. ISBN 9781742242231
    .
  41. ^ "2014 Science Communication Awards: The winning entries". AMRC - Association of Medical Research Charities. Archived from the original on 2014-05-02. Retrieved 2016-09-30.
  42. ^ Peter, Forbes (20 March 2018). "How close are we to a cure for Huntington's?". The Independent. Retrieved 2 December 2021.
  43. ^ Brewer, Kirstie (11 June 2021). "Huntington's disease won't stop me having a baby". BBC News.
  44. ^ "Researcher Hopeful, Sure of Future Cure for Huntington's Disease". Huntington's Disease News. BioNews Network. 22 July 2016.
  45. PMID 27428401
    .
  46. ^ "Watch The Inheritance Online | Vimeo On Demand". Vimeo. Retrieved 2016-03-31.
  47. ^ "Edward Wild". IMDb. Retrieved 4 May 2016.
  48. ^ "Access to Understanding Science Writing Competition 2015" (PDF). Access to Understanding. Europe PubMed Central.
  49. ^ "Huntington's And Immunity - Dr Ed Wild, University College London". The Naked Scientists. 25 October 2009. Retrieved 2016-04-01.
  50. ^ "Listener Week. The Hayes Sisters; Huntington's Disease; Coping with the school holidays on a low income". Woman's Hour. BBC Radio 4. Retrieved 15 July 2016.
  51. ^ "Morning Ireland - Breakthrough made in efforts to counter Huntington's disease". RTE Radio. RTE. Retrieved 2 December 2021.
  52. ^ Burns, Ken. "The Gene - Part 1: Dawn of the Modern Age of Genetics - Episode 1". PBS. Retrieved 2 December 2021.
  53. ^ "Part 1: Dawn of the Modern Age of Genetics". Ken Burns Presents: The Gene. 7 April 2020. Retrieved 2 December 2021.
  54. ^ Raven, Charlotte; Wild, Edward (4 November 2021). Patient 1. Penguin.
  55. ^ "World-Renowned International Huntington Neurologists and Researchers to be featured at the Huntington Society of Canada's National Conference" (PDF). Huntington Society of Canada.
  56. ^ "Carroll receives HDSA Researcher of the Year award". Western Today. Retrieved 2016-03-31.
  57. ^ "UCL HD Centre wins two prestigious 'Insight of the Year' awards". UCL Queen Square Institute of Neurology. September 12, 2017.

External links

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