Eric Topol

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Eric Topol
Born26 June 1954 Edit this on Wikidata
Alma mater
Websitehttps://drerictopol.com/ Edit this on Wikidata
Academic career
FieldsGenetics, cardiology Edit this on Wikidata
Institutions

Eric Jeffrey Topol (born (1954-06-26) June 26, 1954 (age 69))

Scripps Research Institute, and a senior consultant at the Division of Cardiovascular Diseases at Scripps Clinic in La Jolla, California. He has published three bestseller books on the future of medicine:[3] The Creative Destruction of Medicine (2010), The Patient Will See You Now (2015), and Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again (2019). He was commissioned by the UK from 2018–2019 to lead planning for the National Health Service
's future workforce, integrating genomics, digital medicine, and artificial intelligence.

In 2016, Topol was awarded a US$207 million grant from the

Precision Medicine Initiative (All of Us Research Program), a one million American prospective research program.[4]
This funding was renewed in 2023 for $282 million over five years. This is in addition to his role as principal investigator for the Scripps hub of the National Institutes of Health’s Clinical and Translational Science Awards (CTSA) Program, aimed at promoting innovation in medicine and future medical researchers' education and career training. Topol’s group has been supported by the CTSA since 2008, with the most recent funding of $46.8 million being awarded in 2023 for 7 years.

Research

As a researcher, Topol has published over 1,300 peer-reviewed articles, with more than 340,000 citations, 244 h-index, elected to the National Academy of Medicine, and is one of the top 10 most cited researchers in medicine. His principal scientific focus has been on the genomic and digital tools, with the use of artificial intelligence analytics, to individualize medicine. He also pioneered the development of many medications that are routinely used in medical practice including

ReoPro. He has led clinical trials in over 40 countries involving over 200,000 patients (first in series – GUSTO trials).[5]
He has edited over 30 books, including the Textbook of Interventional Cardiology (8th ed - Elsevier, 2020), and the Textbook of Cardiovascular Medicine (3rd ed - Lippincott Williams & Wilkins).

Education and career

Topol completed medical school at the University of Rochester (MD with Honor), his residency in internal medicine at the University of California, San Francisco, and his fellowship in cardiovascular medicine at Johns Hopkins University.[citation needed]

Topol was a tenured professor at the

Cleveland Clinic Lerner College of Medicine, the first new medical school in the US in 20 years, with its first class in 2004, and served as its provost and chief academic officer of the Cleveland Clinic. In 2003 he became a professor of genetics at Case Western Reserve University, while maintaining his primary appointment at Cleveland Clinic.[citation needed
]

Topol departed from the Cleveland Clinic Lerner College of Medicine in 2006 following the removal of the chief academic officer position, and continued at Case Western Reserve University. He was then recruited by

West Wireless Health Institute
, now called West Health Institute, to foster the use of digital tools in medical research and practice.

Medical A.I.

Following the groundbreaking Deep Medicine book, Topol has published multiple original research and review papers in leading peer reviewed journals on medical A.I. In addition, he published a weekly update of all leading peer reviewed medical A.I. papers via Doctor Penguin, and frequent open-access essays on the latest in medical A.I in Ground Truths. In 2023 he also presented a TED Talk[8] on the transformative power of A.I. in medicine. His work on "high-performance medicine" that builds on this report was also published in Nature.[9]

Genetics and genomics

At the

MEF2A deletion reports were recognized as top 10 advances by the American Heart Association in 2000 and 2004. He was the principal investigator of the National Institutes of Health's Specialized Centers of Clinically Oriented Research grant on the genomics of heart attack with a $17M award in 2005. His work in genetics has been recognized by the American College of Cardiology with the Simon Dack Award and Lecture in 2005 and by the European Society of Cardiology by the Andreas Gruentzig Award and Lecture in 2004.[12]

Digital medicine

Topol has been involved with digital medicine since its inception. He has been labeled as the "Dean of Digital Medicine."

Consumer Electronic Show. He led the first trial with the GE Vscan device according to GE Reports, a pocket high resolution, mobile ultrasound imaging device, introduced in the US in 2010. "The Doctor Will “e” You Now" and is currently leading clinical trials of heart rhythm and heart failure monitoring digital devices.[citation needed
]

National Health Service (NHS) - Topol Digital Fellowship

Topol was commissioned by

digital healthcare.[15] More nursing and physician associates would be required, enabling doctors to focus on the most difficult cases.[16] The report also recommended specific digital training for NHS staff and physicians.[15]

Vioxx

Topol served as chairman of cardiovascular medicine at Cleveland Clinic from 1991 to 2005. He was one of the first researchers to question the cardiovascular safety of rofecoxib (Vioxx), culminating in that drug's withdrawal from the market. Topol's advocacy on the subject led to what The New York Times described as an "unusually public dispute" with the Cleveland Clinic's leadership over ties between the academic institution and the pharmaceutical industry,[17] ultimately leading to Topol's departure after his administrative position as head of their academic program was abolished.

In a 2004 editorial in

New England Journal of Medicine, arguing that "neither Merck nor the FDA fulfilled its responsibilities to the public" and encouraging a "full congressional review" of the situation.[19]

In 2004,

Journal of the American Medical Association commentary, Topol pointed to these allegations as an example of the complications that physicians can experience when associating with the investment industry, at the same time reiterating that "no true conflict of interest existed in this case."[21]

In November 2005, Topol was subpoenaed in a

Delos Cosgrove, and stated that Topol's criticism of Merck had focused scrutiny and criticism on the clinic's deep and longstanding ties to the pharmaceutical and medical-device industries.[17]

COVID-19

In August 2020, Topol published an open letter in Medscape to FDA Commissioner

Stephen Hahn, criticizing his Emergency Use Authorizations of hydroxychloroquine, convalescent plasma, and remdesivir for COVID-19. Topol wrote, "These repeated breaches demonstrate your willingness to ignore the lack of scientific evidence, and to be complicit with the Trump Administration's politicization of America's healthcare institutions."[24] Hahn had stated that he was prepared to authorize a vaccine before Phase 3 trials were completed, but Topol said that this would not allow the FDA to establish safety and efficacy, would jeopardize the vaccine program, and would betray the public trust. He called on Hahn to revise his statement or resign.[24]

After conversations with Topol, Hahn retracted some of those claims. In September 2020, Hahn tightened up the rules for approving a vaccine, requiring a longer follow-up period, leading to criticism from Trump. Trump attacked Hahn in a tweet, saying that the rules should be loosened.[25][26] Some argue that this delayed the approval of the Pfizer vaccine by around a month, with the Phase 3 trial endpoints being met on November 8, 2020, 5 days after the presidential election.[27]

Honors

Topol was selected as one of the 12 “Rock Stars of Science” by

National Academy of Sciences.[29] He was named Doctor of the Decade by the Institute for Scientific Information for being one of the top 10 most cited medical researchers. In 2011, Topol received the Hutchinson Medal from the University of Rochester in addition to giving the commencement speech for the School of Medicine and Dentistry. In 2012, Modern Healthcare ranked Topol as the most influential physician executive in the United States.[30]

Personal life

He is married to Susan Merriman Topol with whom he has two children.[1]

Bibliography

  • Topol, Eric J. Deep Medicine, 2019 —
    ISBN 9781541644649[31][32]
  • Topol, Eric J., and Paul S. Teirstein. 1st edition, 1989; Textbook of Interventional Cardiology, 7th edition. Philadelphia, PA: Elsevier, 2015 —
    ISBN 9780323568142
  • Topol, Eric. The Patient Will See You Now: The Future of Medicine Is in Your Hands. New York: Basic Books, 2015 —
    ISBN 9780465054749 [33][34][35]
  • Topol, Eric. The Creative Destruction of Medicine: How the Digital Revolution Will Create Better Health Care. New York: Basic Books, 2012 —
    ISBN 9780465025503[36]

See also

References

  1. ^ a b Eric, Topol (2012-10-01). "Curriculum Vitae Eric J. Topol, M.D" (PDF). stsiweb.org. Archived (PDF) from the original on 2013-01-20. Retrieved 2018-02-14.
  2. ^ Scripps Translational Science Institute
  3. ISBN 9781541644632
    . Retrieved March 3, 2019.
  4. ^ Comstock, Jonah (6 October 2016). "NIH expands grant for Scripps-led Precision Medicine group to $207M". MobiHealthNews. HIMSS Media.
  5. PMID 8204123
    .
  6. ^ "Cleveland Clinic Boasts the Nation's Top Heart Center for the 15th Straight Year". Cleveland Leader. 2009. Archived from the original on 2010-02-13.
  7. ^ "Noted Cardiologist Eric J. Topol Comes to Scripps". 15 February 2008.
  8. ^ "ERIC TOPOL, Founder & Executive VP, Scripps Research Institute". TED AI. Retrieved 2024-01-05.
  9. S2CID 57574615
    .
  10. PMID 6388898
    .
  11. ISSN 0009-7322
    .
  12. ^ "Archived copy". Archived from the original on 2011-07-26. Retrieved 2010-07-24.{{cite web}}: CS1 maint: archived copy as title (link)
  13. ^ Americas, U. B. M. "'The Dean of Digital Medicine,' Dr. Eric J. Topol, Selected as Keynote Presenter at Medical Design and Manufacturing (MD&M) Minneapolis". www.prnewswire.com. Retrieved 2024-04-22.
  14. ^ "How do genetics and wireless medicine prevent disease?". TEDMED. Retrieved 2024-01-11.
  15. ^ a b "The Topol Review — NHS Health Education England". The Topol Review — NHS Health Education England. Retrieved 2020-03-11.
  16. ^ "Could patients become their own doctors?". BBC. 12 February 2019. Retrieved 14 February 2019.
  17. ^ a b c Abelson, Reed; Saul, Stephanie (December 17, 2005). "Ties to Industry Cloud a Clinic's Mission". The New York Times. Retrieved July 16, 2010.
  18. ^ Topol, Eric (October 2, 2004). "Good Riddance to a Bad Drug". The New York Times. Retrieved July 9, 2010.
  19. S2CID 12516952
    .
  20. ^ McLean, Bethany (December 13, 2004). "A Bitter Pill for One Merck Critic". Fortune. Retrieved July 16, 2010.
  21. PMID 15928288
    .
  22. ^ Feeley, Jef; Laurel Brubaker Calkins (December 3, 2005). "Merck's Vioxx Posed 'Extraordinary' Risk, Cardiologist Contends". Bloomberg. Retrieved July 24, 2010.
  23. ISBN 978-1-59420-230-8
    .
  24. ^ a b Eric Topol (August 31, 2020). "Dear Commissioner Hahn: Tell the Truth or Resign. An Open Letter to Stephen Hahn, MD, From Eric Topol, MD". Medscape.
  25. S2CID 222413062
    .
  26. ^ Regalado, Antonio, One doctor’s campaign to stop a covid-19 vaccine being rushed through before Election Day, MIT Technology Review, October 19, 2020
  27. ^ LaFraniere, Sharon; Thomas, Katie; Weiland, Noah; Gelles, David; Stolberg, Sheryl Gay; Grady, Denise (21 November 2020). "Politics, Science and the Remarkable Race for a Coronavirus Vaccine". The New York Times. Retrieved 18 August 2021.
  28. ^ "Eric Topol". Geoffrey Beene Rock Stars of Science. Geoffrey Beene Foundation. 2009. Archived from the original on 2 June 2013. Retrieved 2010-05-12.
  29. ^ Stencel, Christine; Shamir, Judith (18 October 2004). "Institute of Medicine Elects 65 New Members, Five Foreign Associates" (Press release). Washington: The National Academies of Sciences, Engineering, and Medicine. Archived from the original on 31 October 2006.
  30. ^ Robbins, Gary (21 April 2012). "San Diego's Topol named nation's top physician executive". San Diego Union–Tribune. Archived from the original on 19 May 2012. Retrieved 2012-04-23.
  31. ^ "Review of Deep Medicine by Eric Topol". Kirkus Reviews. 2019.
  32. ^ Atkinson, Robert D. (2019). "Review of Deep Medicine by Eric Topol". New York Journal of Books.
  33. ^ Chitty, Mary (January 14, 2015). "The Future According to Topol". Clinical Informatics News. Needham, Massachusetts, United States: Cambridge Healthtech Institute. Archived from the original on January 22, 2015. Retrieved January 20, 2015.
  34. ^ Jauhar, Sandeep (13 February 2015). "Review of "The Patient Will See You Now" by Eric Topol". The New York Times.
  35. ^ Klass, Perri (16 January 2015). "Review of "The Patient Will See You Now" by Eric Topol". The Washington Post.
  36. PMC 3810531
    .

Further reading

External links

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