FBXO11
| FBXO11 | |||
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| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) |
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| RefSeq (protein) |
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| Location (UCSC) | Chr 2: 47.79 – 47.91 Mb | Chr 17: 88.3 – 88.37 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
F-box only protein 11 is a protein that in humans is encoded by the FBXO11 gene.[5][6][7][8]
Function
This gene encodes a member of the
WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.[8]
FBXO11 is conserved from
tumorigenesis, and tumor cell metastasis. Well established targets of FBXO11 include BCL6,[9] CDT2,[10][11] and Snail.[12]
Clinical significance
Inactivation of FBXO11-mediated BCL6 degradation has been shown to contribute to abnormal germinal-center formation and tumorigenesis.haploinsufficient mutant alleles cause otitis media, a disorder that affects approximately 15% of children.[15]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000138081 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005371 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 7467493.
- PMID 16487488.
- PMID 18162545.
- ^ a b "Entrez Gene: FBXO11 F-box protein 11".
- ^ PMID 22113614.
- PMID 23478445.
- PMID 23478441.
- PMID 25203322.
- PMID 27166359.
- ^ Dev Cell. 2014 Mar 31;28(6):697-710. doi: 10.1016/j.devcel.2014.01.028. DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation. Horn M, Geisen C, Cermak L, Becker B, Nakamura S, Klein C, Pagano M, Antebi A.
- PMID 17035249.
Further reading
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (October 1999). "A family of mammalian F-box proteins". Current Biology. 9 (20): 1180–2. S2CID 14341845.
- Le Poole IC, Sarangarajan R, Zhao Y, Stennett LS, Brown TL, Sheth P, Miki T, Boissy RE (December 2001). "'VIT1', a novel gene associated with vitiligo". Pigment Cell Research. 14 (6): 475–84. PMID 11775060.
- Segade F, Daly KA, Allred D, Hicks PJ, Cox M, Brown M, Hardisty-Hughes RE, Brown SD, Rich SS, Bowden DW (July 2006). "Association of the FBXO11 gene with chronic otitis media with effusion and recurrent otitis media: the Minnesota COME/ROM Family Study". Archives of Otolaryngology–Head & Neck Surgery. 132 (7): 729–33. PMID 16847180.
- Abida WM, Nikolaev A, Zhao W, Zhang W, Gu W (January 2007). "FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity". The Journal of Biological Chemistry. 282 (3): 1797–804. PMID 17098746.
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