Falcarinol
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Names | |
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IUPAC name
(3S,9Z)-Heptadeca-1,9-diene-4,6-diyn-3-ol
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Other names
Carotatoxin, panaxynol
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Identifiers | |
3D model (
JSmol ) |
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ChemSpider | |
KEGG | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C17H24O | |
Molar mass | 244.378 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Falcarinol (also known as carotatoxin or panaxynol) is a natural pesticide and
Chemistry
Falcarinol is a polyyne with two carbon-carbon triple bonds and two double bonds.[3] The double bond at the carbon 9 position has cis stereochemistry was introduced by the desaturation, which requires oxygen and NADPH (or NADH) cofactors and creates a bend in the molecule. It is structurally related to oenanthotoxin and cicutoxin.
Biological effects
Falcarinol is an intense irritant that can cause
Biosynthesis
![](http://upload.wikimedia.org/wikipedia/commons/thumb/1/13/Falcarinol_-_Natural_Product_copy.png/220px-Falcarinol_-_Natural_Product_copy.png)
Starting with oleic acid (1), which possesses a cis double bond at the carbon 9 position from desaturation and a bound of phospholipids (-PL), a bifunctional desaturase/acetylnase system occurred with oxygen (a) to introduce the second cis double bond at the carbon 12 position to form linoleic acid (2). This step was then repeated to turn the cis double bond at the carbon 12 position into a triple bond (also called acetylenic bond) to form crepenynic acid (3). Crepenynic acid was reacted with oxygen (b) to form a second cis double bond at the carbon 14 position (conjugated position) leading to the formation of dehydrocrepenynic acid (4). Allylic isomerization (c) was responsible for the changes from the cis double bond at the carbon 14 position into the triple bond (5) and formation of the more favored trans (E) double bond at the carbon 17 position (6). Finally, after forming the intermediate (7) by decarboxylation (d), falcarinol (8) was produced by hydroxylation (e) at the carbon 16 position that introduced the (R)-configuration to the system.[7]
See also
References
- .
- ISBN 968-444-071-5.
- .
- .
- PMID 20206138.
- ISBN 978-0-8247-0760-6.
- ISBN 978-0-470-74168-9.