glycophosphatidylinositol (GPI anchor) linkage and two integral transmembrane forms.[2] The larger transmembrane form has an amino acid motif contained in its cytoplasmic domain that is rich in proline, glutamic acid, serine and threonine residues (PEST sequence).[2] The fasciclin 1 (Fas1) and fasciclin 3 (Fas3) genes in Drosophila also code for cell adhesion proteins in the nervous system but do not show any structural or functional similarities with NCAM.[2]
FasII is initially expressed selectively localized to basolateral junctions during the process of
neuroblasts at early stages of neurogenesis where its function is not fully understood but might be involved in proneural gene induction.[2]
Other roles for fasII include delineating two axonal pathways in the adult ocellar sensory system (OSS) via its expression on ocellar pioneer (OP) neurons where it acts to promote
