Glioma 261
Glioma 261 (GL261) is a frequently used
murine glioma model. It was induced via intracranial injection of methylcholanthrene followed by serial intracranial and subcutaneous transplantations of tumor fragments into syngeneic C57BL/6 mice.[1][2] By the mid-1990s, multiple groups had established a permanent cell line
from the tumor.
GL261 tumors resemble
B7-2. The tumors are invasive, are not known to be metastatic, and do not spontaneously regress.[3][4]
Other immunocompetent murine models used to study GBM include GL26, CT-2A, SMA-560, and 4C8.[5]
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