Glycol cleavage
Glycol cleavage is a specific type of organic chemistry
Glycol cleavage is an important for determining the structures of sugars. After cleavage of the glycol, the ketone and aldehyde fragments can be inspected and the location of the former hydroxyl groups ascertained.[2]
Reagents
Iodine-based reagents such as
Cyclic intermediate are invariably invoked. The ring then fragments, with cleavage of the carbon–carbon bond and formation of carbonyl groups.
Warm concentrated potassium permanganate (KMnO4) will react with an alkene to form a glycol. Following this dihydroxylation, the KMnO4 can then cleave the glycol to give aldehydes or ketones. The aldehydes will react further with (KMnO4), being oxidized to become carboxylic acids. Controlling the temperature, concentration of the reagent and the pH of the solution can keep the reaction from continuing past the formation of the glycol.
References
- ^ ISBN 978-0-471-72091-1
- ISBN 0-13-147882-6.)
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- PMID 20192259.