Gurken localisation signal

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Gurken localisation signal
Eukaryota
SOSO:0005836
PDB structuresPDBe

mRNA localization is a common mode of posttranscriptional regulation of gene expression that targets a protein to its site of function.[1] Proteins are highly dependent on cellular environments for stability and function, therefore, mRNA localization signals are crucial for maintaining protein function. The Gurken localisation signal is an RNA regulatory element conserved across many species of Drosophila. The element consists of an RNA stem loop within the coding region of the messenger RNA that forms a signal for dynein-mediated Gurken mRNA transport to the dorsoanterior cap near the nucleus of the oocyte.[2]

Mechanism of action

During Drosophila oogenesis, signaling between the

poly(A) tail determines the stage in oogenesis at which the gurken protein is adenylated.[3]
30-50 gurken adenlyated residues are associated in initial oogenesis whilst 50-90 adenlyated residues are associated with late-stage oogenesis.

The major difference between the gurken localization signal and other localization signals is that gurken localization signals are distributed throughout coding regions, whereas the majority of the other localization signals are found in

3' untranslated regions.[9].[4] The gurken localization signal does not function properly if it is located in the 3' untranslated region.[4]

References

  1. PMID 15145355
    .
  2. PMID 15992540
    .
  3. ^ a b c Brody, Thomas B. "Factors affecting Gurken mRNA localization and translation (part 2/2)". The Interactive Fly. Retrieved 1 May 2020 – via Society for Developmental Biology's Web server.
  4. ^
    PMID 10790337
    .

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