Haploidisation

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Haploidisation is the process of halving the chromosomal content of a cell, producing a

haploid cell. Within the normal reproductive cycle, haploidisation is one of the major functional consequences of meiosis, the other being a process of chromosomal crossover that mingles the genetic content of the parental chromosomes.[1]
Usually, haploidisation creates a monoploid cell from a diploid progenitor, or it can involve halving of a polyploid cell, for example to make a diploid potato plant from a tetraploid lineage of potato plants.

If haploidisation is not followed by fertilisation, the result is a haploid lineage of cells. For example, experimental haploidisation may be used to recover a strain of haploid Dictyostelium from a diploid strain.[2] It sometimes occurs naturally in plants when meiotically reduced cells (usually egg cells) develop by parthenogenesis.

Haploidisation was one of the procedures used by Japanese researchers to produce Kaguya, a mouse which had same-sex parents; two haploids were then combined to make the diploid mouse.

Haploidisation commitment is a checkpoint in meiosis which follows the successful completion of premeiotic DNA replication and recombination commitment.[3]

See also

References

  1. ^ ML Kothari, L Mehta (2002). "Bipolar hermaphroditism of somatic cell as the basis of its being and becoming: celldom appreciated". Journal of Postgraduate Medicine. 48 (3).
  2. PMID 7227041
    .
  3. PMID 762020
    .
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