Hexadimethrine bromide
| |
| Names | |
|---|---|
| IUPAC name
1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide
| |
| Other names
Polybrene
| |
| Identifiers | |
| ChemSpider |
|
ECHA InfoCard
|
100.209.698 |
| EC Number |
|
| UNII | |
CompTox Dashboard (EPA)
|
|
| Properties | |
| (C13H30Br2N2)n, linear form | |
| Molar mass | variable |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
Hexadimethrine bromide (commercial brand name Polybrene) is a
Hexadimethrine bromide also reverses heparin anticoagulation during open-heart surgery, and it was the original reversal agents used in the 1950s and 1960s.[5] It was replaced by protamine sulfate in 1969, after it was shown that hexadimethrine bromide could potentially cause kidney failure in dogs when used in doses in excess of its therapeutic range.[6] It is still used as an alternative to protamine sulfate for patients who are sensitive to protamine, and at least one surgical center has gone back to using it as their standard reversal agent, since protamine sulfate causes at least a mild hypotensive reaction in most or all patients [5]
Hexadimethrine bromide is also used in enzyme kinetic assays in order to reduce spontaneous activation of zymogens that are prone to auto activation.[citation needed]
References
 | This genetics article is a stub. You can help Wikipedia by expanding it. |
 | This article about polymer science is a stub. You can help Wikipedia by expanding it. |