Hirano body
Hirano bodies are intracellular aggregates of actin and actin-associated proteins first observed in neurons (nerve cells) by Asao Hirano in 1965.[1] The eponym ‘Hirano bodies’ was not introduced until 1968, by Schochet et al., three years after Hirano first observed the proteins.[2]
Hirano bodies are found in the nerve cells of individuals afflicted with certain neurodegenerative disorders, such as Alzheimer's disease and Creutzfeldt–Jakob disease.[3]
Hirano bodies were first described in the CA1 in patients with
Hirano bodies have been noted as a function of age without obvious underlying neurodegeneration.[7]
Alzheimer's disease
The Sommer’s sector (CA1) of the hippocampus has been described to be influential in the formation of new memories, as well as, containing inclusion bodies that contribute to a hallmark of Alzheimer’s disease (AD), intellectual deficit.[2] Alzheimer’s neurofibrillary tangles show a preference to form in the CA1, which is one of the major areas in which Hb’s have been observed.[2] There are a larger number of Hb’s found in people with Alzheimer’s disease than those without the disease.[4] Additionally many processes of Alzheimer’s neurofibrillary tangles have been observed to contain Hirano bodies.[2]
Hirano bodies are described as cytoplasmic paracrystalline lattices, which are a main form of a pathological feature seen in a broad spectrum of
Notes
- ^ University of Edinburgh Archived 2013-10-02 at the Wayback Machine, Hirano bodies, citing Hirano, Asao. (1965) "Pathology of amyotrophic lateral sclerosis," in Slow Latent and Temperate Virus Infections, National Institute of Neurological Diseases and Blindness (NINDB) monograph No.2, pp. 23-37.
- ^ S2CID 23942573.
- PMID 2984334.
- ^ PMID 2468822.
- ISBN 978-0-7216-7335-6.
- ^ Maselli, A. G., Davis, R., Furukawa, R. and Fechheimer, M. (2002)."Formation of Hirano bodies in Dictyostelium and mammalian cells induces by expression of a modified form of an actin-crosslinking protein," J.Cell Sci. 115, 1939-1952.
- S2CID 32228762.
- PMID 19479823.
- ^ PMID 16203860.
- S2CID 84120926.
References
- National Institute of Neurological Diseases and Blindness. OCLC 463013735
- S2CID 23942573.