Hybrid mass spectrometer

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A hybrid mass spectrometer is a device for

m/z
separation devices of different types.

Notation

Schematic of a quadrupole time-of-flight (QTOF) mass spectrometer.

The different m/z separation elements of a hybrid

time-of-flight mass spectrometer, B is a magnetic sector
and E is an electric sector.

Sector quadrupole

A

sector instrument can be combined with a collision quadrupole and quadrupole mass analyzer to form a hybrid instrument.[1] A BEqQ configuration with a magnetic sector (B), electric sector (E), collision quadrupole (q) and m/z selection quadrupole (Q) have been constructed[2][3] and an instrument with two electric sectors (BEEQ) has been described.[4]

Quadrupole time-of-flight

Hybrid quadrupole time-of-flight mass spectrometer.

A triple quadrupole mass spectrometer with the final quadrupole replaced by a time-of-flight device is known as a quadrupole time-of-flight instrument.[5][6] Such an instrument can be represented as QqTOF.

Ion trap time-of-flight

In an ion trap instrument, ions are trapped in a quadrupole ion trap and then injected into the TOF. The trap can be 3-D[7] or a linear trap.[8]

Linear ion trap and Fourier transform mass analyzers

Hybrid linear ion trap Fourier transform ion cyclotron resonance mass spectrometer

A linear ion trap combined with a

Thermo Scientific
as the LTQ FT and LTQ Orbitrap, respectively.

References

  1. doi:10.1016/0020-7381(82)85032-8
    .
  2. doi:10.1016/0168-1176(85)85059-X
    .
  3. doi:10.1016/0168-1176(86)85020-0
    .
  4. doi:10.1063/1.1143391
    .
  5. PMID 10815976
    .
  6. PMID 11473401
    .
  7. PMID 7517726
    .
  8. doi:10.1002/(SICI)1097-0231(19981030)12:20<1463::AID-RCM357>3.0.CO;2-H
    .
  9. PMID 15253445
    .
  10. PMID 16579588
    .
  11. PMID 16249172
    .
  12. PMID 16408932
    .
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