Source: Wikipedia, the free encyclopedia.
Protein-coding gene in the species Homo sapiens
IGF2BP1 Available structures Gene ontology
Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Wikidata
Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene .[5] [6] [7]
This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four
mRNA and regulating IGF2 translation.
[7] See also References Further reading
Perycz M, Urbanska AS, Krawczyk P, Parobczak K, Jaworski J (2011). "Zipcode binding protein 1 regulates the development of dendritic arbors in hippocampal neurons" . J. Neurosci . 31 (14): 5271–85. . Yisraeli JK (2005). "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins" . Biol. Cell . 97 (1): 87–96. . Prokipcak RD, Herrick DJ, Ross J (1994). "Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA" . J. Biol. Chem . 269 (12): 9261–9. . Doyle GA, Betz NA, Leeds PF, et al. (1999). "The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins" . Nucleic Acids Res . 26 (22): 5036–44. . Runge S, Nielsen FC, Nielsen J, et al. (2000). "H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein" . J. Biol. Chem . 275 (38): 29562–9. . Nielsen FC, Nielsen J, Kristensen MA, et al. (2003). "Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domains". J. Cell Sci . 115 (Pt 10): 2087–97. . Lemm I, Ross J (2002). "Regulation of c-myc mRNA Decay by Translational Pausing in a Coding Region Instability Determinant" . Mol. Cell. Biol . 22 (12): 3959–69. . Ioannidis P, Mahaira L, Papadopoulou A, et al. (2003). "8q24 Copy number gains and expression of the c-myc mRNA stabilizing protein CRD-BP in primary breast carcinomas" . Int. J. Cancer . 104 (1): 54–9. . Nielsen J, Adolph SK, Rajpert-De Meyts E, et al. (2003). "Nuclear transit of human zipcode-binding protein IMP1" . Biochem. J . 376 (Pt 2): 383–91. . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. . Gu L, Shigemasa K, Ohama K (2004). "Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer". Int. J. Oncol . 24 (3): 671–8. . Hansen TV, Hammer NA, Nielsen J, et al. (2004). "Dwarfism and Impaired Gut Development in Insulin-Like Growth Factor II mRNA-Binding Protein 1-Deficient Mice" . Mol. Cell. Biol . 24 (10): 4448–64. . Ioannidis P, Kottaridi C, Dimitriadis E, et al. (2004). "Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors". Cancer Lett . 209 (2): 245–50. . Rackham O, Brown CM (2005). "Visualization of RNA–protein interactions in living cells: FMRP and IMP1 interact on mRNAs" . EMBO J . 23 (16): 3346–55. . Nielsen J, Kristensen MA, Willemoës M, et al. (2004). "Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability" . Nucleic Acids Res . 32 (14): 4368–76. . Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions" . Genome Res . 14 (9): 1711–8. . Liao B, Patel M, Hu Y, et al. (2005). "Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells" . J. Biol. Chem . 279 (47): 48716–24. .
