Jeffrey Flier

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Jeffrey Flier
21st Dean of the Harvard Medical School
In office
September 1, 2007 – July 31, 2016
Personal details
Born
Jeffrey Scott Flier

(1948-02-27) February 27, 1948 (age 76)
New York, New York
SpouseEleftheria Maratos-Flier
Children2
WebsiteDean of the Faculty of Medicine

Jeffrey Flier is an American physician, endocrinologist; widely cited scientist; the Higginson Professor of Medicine and Physiology at Harvard Medical School; and a Distinguished Service Professor at the same institution. He was the 21st Dean of the Faculty of Medicine at Harvard University from 2007 to 2016.[1][2][3]

Early life and career

Flier was born in

Mount Sinai Hospital, he spent four years in the Public Health Service as a clinical associate at the National Institutes of Health, completing training in endocrinology and launching a research career. He moved to Boston in 1978, becoming an assistant professor of medicine at Harvard Medical School, and chief of the Diabetes Unit at Harvard-affiliated Beth Israel Hospital. He subsequently became chief of the hospital's Endocrinology Division, vice chair for research of the Department of Medicine, and eventually the hospital's chief academic officer in 2002, overseeing research and educational affairs. At Harvard Medical School, he became the George C. Reisman Professor of Medicine, and Harvard faculty dean for Academic Affairs at what became the Beth Israel Deaconess Medical Center.[3] At BIDMC he served as a Chief Academic Officer from 2002 to 2007.[6]

Appointment as Dean of Harvard's Faculty of Medicine

Flier was appointed Dean of the Faculty of Medicine and the Caroline Shields Walker professor of medicine at Harvard in July 2007 by President Drew Faust and assumed the position on September 1, 2007.[3] During his first year as dean, he led an extensive strategic planning process, releasing a report in October 2008.[7] Harvard University and Harvard Medical School suffered financial losses when financial markets fell in 2008–2009. This slowed but did not stop investments in several areas.[8] His term as dean of Harvard Medical School ended in 2016 after nine years.[9]

Some of the corporate accomplishments corresponding to his period as a Dean were: 1. implementation of a new Clinical and Translational Science Award from NIH;[10] 2. successful launch and oversight of the $750 million “The World is Waiting” capital campaign;[11] 3. implementation of a major redesign of the preclinical medical curriculum;[12] 4. design and implementation of a new system for financial contributions to HMS from its affiliated institutions;[11] 5. establishment of a new department of biomedical informatics;[13] 6. establishment of a new division of external education, combining Harvard Health Publishing, postgraduate medical education, and new HMS online learning and executive education programs designed to increase the global impact and educational revenues of the institution.[14] Flier's 2016 final class commencement speech at Harvard Medical School is available online.[15]

Research contributions

While at the Diabetes Branch of NIH, under the mentorship of

membrane receptor
biology and provided an important tool for research on insulin action.
FGF21 in metabolic regulation.[28] With Bruce Spiegelman he discovered an altered production of adipsin in obesity in genetically obese mice.[29] In 2005, he reported the possible role of adult hypothalamic neurogenesis in the control of energy balance;[30] Regarding inflammatory phenomena in metabolic disease, Flier helped establish that Toll-like receptor 4 (TLR4) activation in adipocytes and macrophages mediates inflammation accompanying obesity, and subsequent insulin resistance in diabetes.[31] In 1980 he described a rare case of familial acanthosis nigricans-muscle cramps-acral enlargement syndrome.[32]

Opinion

Since stepping down as dean, Flier has increasingly contributed policy-oriented publications focusing on a number of issues affecting health care and biomedical research in current times, among them: health care reform[33] and its sustainability,[34] enhancing US health provider workforce,[35] the pros and cons of prevailing credit attribution practices in academia and industry,[36] the realities and options linked to the irreproducibility of research results,[37] improving the institutional handling of scientific misconduct,[38] the obsolescence of distinctions between basic and translational biomedical research,[39] and the complexities behind conflict of interest (COI) disclosure.[40]

Flier has taught, mentored and promoted the career development of diverse trainees, faculty, scientists, physicians, and leaders over several decades. He has questioned the blanket and often ineffective approach toward DEI (diversity, equity, inclusion) initiatives. He does not support mandatory diversity statements in faculty applications.

editorializing]. He and other leaders have asked for an objective and fair-minded adjudication for Dr. David M. Sabatini, a biologist who was fired by the Howard Hughes Medical Institute and resigned from the Whitehead Institute and MIT following an allegation of sexual misconduct.[43]

Personal life

Flier is married to Eleftheria Maratos-Flier. She is an endocrinologist and Professor of Medicine at Harvard Medical School,[44] and currently a director of clinical research at Alynylam Pharmaceuticals. The two have collaborated in several areas of research.[27][21][23] They have two daughters. Sarah and Lydia, both of whom are physicians.[45]

Honors/affiliations/awards

  • Institute of Medicine of the National Academies of Science [5]
  • American Academy of Arts and Sciences [5]
  • American Society for Clinical Investigation[3]
  • Association of American Physicians [3]
  • Eli Lilly Award, American Diabetes Association [5]
  • Banting Medal, American Diabetes Association [5]
  • Solomon Berson Lecture, American Physiological Society [5]
  • Albert Renold Award, American Diabetes Association [46]
  • Astwood Lecture, Endocrine Society [5]
  • Honorary Doctor of Science, University of Athens [5]
  • Doctor of Science, Honoris Causa, University of Edinburgh [47]
  • Advisory Council, National Institutes of Diabetes and Digestive and Kidney Diseases, NIH [48]

Selected works

Scholia has a profile for Jeffrey Scott Flier (Q6176271).

Biomedical Research

Flier has published over 350 research papers papers and subject reviews, which have been jointly cited over 110.000 times, his overall h-index is 150.[49]

Most cited original research

His most cited original research papers are:

  • Frederich, R. C.; Hamann, A.; Anderson, S.; Löllmann, B.; Lowell, B. B.; Flier, J. S. (1995-12). "Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action". Nature Medicine. 1 (12): 1311–1314.
    PMID
     7489415. Cited 1998 times, June 2022
  • Ahima, R. S.; Prabakaran, D.; Mantzoros, C.; Qu, D.; Lowell, B.; Maratos-Flier, E.; Flier, J. S. (1996-07-18). "Role of leptin in the neuroendocrine response to fasting". Nature. 382 (6588): 250–252.
    PMID
     8717038. Cited 3870 times, June 2022
  • Masuzaki, H.; Paterson, J.; Shinyama, H.; Morton, N. M.; Mullins, J. J.; Seckl, J. R.; Flier, J. S. (2001-12-07). "A transgenic model of visceral obesity and the metabolic syndrome". Science. 294 (5549): 2166–2170.
    PMID
     11739957. Cited 227 times, June 2022
  • Shi, Hang; Kokoeva, Maia V.; Inouye, Karen; Tzameli, Iphigenia; Yin, Huali; Flier, Jeffrey S. (2006–11). "TLR4 links innate immunity and fatty acid-induced insulin resistance". The Journal of Clinical Investigation. 116 (11): 3015–3025.
    PMID
     17053832. Cited 3854 times, June 2022
  • Badman, Michael K.; Pissios, Pavlos; Kennedy, Adam R.; Koukos, George; Flier, Jeffrey S.; Maratos-Flier, Eleftheria (2007-06). "Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states". Cell Metabolism. 5 (6): 426–437.
    PMID
     17550778. Cited 1516 times, June 2022
  • Fisher, Ffolliott M.; Kleiner, Sandra; Douris, Nicholas; Fox, Elliott C.; Mepani, Rina J.; Verdeguer, Francisco; Wu, Jun; Kharitonenkov, Alexei; Flier, Jeffrey S.; Maratos-Flier, Eleftheria; Spiegelman, Bruce M. (2012-02-01). "FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis". Genes & Development. 26 (3): 271–281.
    PMID
     22302939. Cited 1373 times, June 2022

Most cited subject reviews

  • Spiegelman, B. M.; Flier, J. S. (1996-11-01). "Adipogenesis and obesity: rounding out the big picture". Cell. 87 (3): 377–389.
    PMID
     8898192. Cited 1615 times, June 2022
  • Ahima, R. S.; Flier, J. S. (2000). "Leptin". Annual Review of Physiology. 62: 413–437.
    PMID
     10845097. Cited 2606 times, June 2022
  • Kahn, Barbara B.; Flier, Jeffrey S. (2000-08-15). "Obesity and insulin resistance". Journal of Clinical Investigation. 106 (4): 473–481.
    PMID
     10953022. Cited 4115 times, June 2022
  • Spiegelman, B. M.; Flier, J. S. (2001-02-23). "Obesity and the regulation of energy balance". Cell. 104 (4): 531–543.
    PMID
     11239410. Cited 2993 times, June 2022
  • Kershaw, Erin E.; Flier, Jeffrey S. (2004–06). "Adipose tissue as an endocrine organ". The Journal of Clinical Endocrinology and Metabolism. 89 (6): 2548–2556.
    PMID
     15181022. Cited 6496 times, June 2022
  • Flier, Jeffrey S. (2004-01-23). "Obesity wars: molecular progress confronts an expanding epidemic". Cell. 116 (2): 337–350.
    PMID
     14744442. Cited 1589 times, June 2022.

Most recent biomedical papers

  • Flier, Jeffrey S.; Maratos-Flier, Eleftheria (2017-07-05). "Leptin's Physiologic Role: Does the Emperor of Energy Balance Have No Clothes?". Cell Metabolism. 26 (1): 24–26.
    PMID
     28648981
  • Douris, Nicholas; Desai, Bhavna N.; Fisher, Ffolliott M.; Cisu, Theodore; Fowler, Alan J.; Zarebidaki, Eleen; Nguyen, Ngoc Ly T.; Morgan, Donald A.; Bartness, Timothy J.; Rahmouni, Kamal; Flier, Jeffrey S. (2017-08). "Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice". Molecular Metabolism. 6 (8): 854–862.
    PMID
     28752049
  • Desai, Bhavna N.; Singhal, Garima; Watanabe, Mikiko; Stevanovic, Darko; Lundasen, Thomas; Fisher, Ffolliott M.; Mather, Marie L.; Vardeh, Hilde G.; Douris, Nicholas; Adams, Andrew C.; Nasser, Imad A. (2017-11). "Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury". Molecular Metabolism. 6 (11): 1395–1406.
    PMID
     29107287
  • Singhal, Garima; Kumar, Gaurav; Chan, Suzanne; Fisher, Ffolliott M.; Ma, Yong; Vardeh, Hilde G.; Nasser, Imad A.; Flier, Jeffrey S.; Maratos-Flier, Eleftheria (2018-07). "Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet". Molecular Metabolism. 13: 56–66.
    PMID
     29753678
  • Watanabe, Mikiko; Singhal, Garima; Fisher, Ffolliott M.; Beck, Thomas C.; Morgan, Donald A.; Socciarelli, Fabio; Mather, Marie L.; Risi, Renata; Bourke, Jared; Rahmouni, Kamal; McGuinness, Owen P. (2020-01). "Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis". Endocrine. 67 (1): 95–108.
    PMID
     31728756
  • Flier, Jeffrey S. (2020-05-01). "Might β3-adrenergic receptor agonists be useful in disorders of glucose homeostasis?". The Journal of Clinical Investigation. 130 (5): 2180–2182.
    PMID
     32202511

Recent policy papers

  • Flier, Jeffrey S. (2019). "Credit and Priority in Scientific Discovery: A Scientist's Perspective". Perspectives in Biology and Medicine. 62 (2): 189–215.
    ISSN
     1529-8795
  • Flier, Jeffrey S. (2019-06-03). "Academia and industry: allocating credit for discovery and development of new therapies". The Journal of Clinical Investigation. 129 (6): 2172–2174.
    ISSN
     0021-9738
  • Flier, Jeffrey S.; Rhoads, Jared M. (2020). "The US Health Provider Workforce: Determinants and Potential Paths to Enhancement". Perspectives in Biology and Medicine. 63 (4): 644–668.
    PMID
     33416803
  • Flier, Jeffrey S. (2021). "Misconduct in Bioscience Research: a 40-year perspective". Perspectives in Biology and Medicine. 64 (4): 437–456.
    ISSN
     1529-8795

Notes

See also:
Mount Sinai School of Medicine § Notable alumni and faculty, Gairdner Foundation § Medical Advisory Board, List of City College of New York people § Science and technology, List of Bronx High School of Science alumni § Academia, and Bronx High School of Science § Other notable alumni and former students

References

  1. ^ "Jeffrey S Flier". hms.harvard.edu. Retrieved 2022-06-12.
  2. ^ "Jeffrey S. Flier". neuro.hms.harvard.edu. May 2020. Retrieved 2022-08-15.
  3. ^ a b c d e "Jeffrey S. Flier named next dean of Faculty of Medicine". Harvard Gazette. 11 July 2007.
  4. ^ "Dorothy Flier Obituary - Brookline, MA". Dignity Memorial.
  5. ^ a b c d e f g h An opponent to healthcare for all. "Jeffrey S. Flier, MD, Dean of Harvard Medical School". Archived from the original on 2010-04-13.
  6. ^ "Jeffrey S. Flier, MD". scholarrock.com.
  7. ^ "Strategic Planning at Harvard Medical School" (PDF). October 2008. Archived from the original (PDF) on 2012-03-10. Retrieved 2010-10-13.
  8. ^ "The Dean's Report 2008-2009" (PDF). 2008. Archived from the original (PDF) on 2012-03-10. Retrieved 2010-10-13.
  9. ^ Flier, Jeffrey. "New Dean for Faculty of Medicine". Harvard Medical School. Retrieved 9 August 2016.
  10. ^ "About". catalyst.harvard.edu. Retrieved 2022-08-15.
  11. ^ a b ""The World Is Waiting"". Harvard Magazine. 2014-11-14. Retrieved 2022-08-15.
  12. ^ "Medical School Overhauls Curriculum With Major Redesign | News | The Harvard Crimson". www.thecrimson.com. Retrieved 2022-08-15.
  13. ^ "HMS To Launch Biomedical Informatics Department | News | The Harvard Crimson". www.thecrimson.com. Retrieved 2022-08-15.
  14. ^ "Office for External Education". hms.harvard.edu. Retrieved 2022-08-15.
  15. ^ School, Harvard Medical (2016-05-26), HMS Class Day address by Jeffrey S. Flier - 2016, retrieved 2022-08-18
  16. S2CID 42644407
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  18. PMID 279910
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  19. PMID 2460770
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  20. PMID 2168397
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  21. ^ a b Flier JS, Maratos-Flier E (1990). "Biology of Obesity". Harrison's Principles of Internal Medicine. Archived from the original on 2010-08-19. Retrieved 2010-10-13.
  22. PMID 14744442
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  23. ^ a b Flier JS, Maratos-Flier E (September 2007). "What fuels fat". Scientific American. 297 (3): 72–81.
    PMID 17784627
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  24. S2CID 4244632
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  26. S2CID 8086930
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  27. ^
    S2CID 4370377
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  28. PMID 17550778
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  29. PMID 3299706
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  30. S2CID 35162566
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  31. PMID 17053832
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  32. PMID 6997748
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  33. PMID 20069708
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  34. ^ Flier, Jeffrey (17 November 2009). "Health 'Reform' Gets a Failing Grade". Wall Street Journal. Retrieved 16 August 2012.
  35. S2CID 229355605
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  36. S2CID 132797746
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  37. PMID 29117541
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  38. S2CID 244724698
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  39. PMID 28765169
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  40. PMID 28464148
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  41. ^ Flier, Jeffrey (January 3, 2019). "Against diversity statements". The Chronicle of Higher Education. Retrieved February 6, 2023.
  42. ^ Flier, Jeffrey (June 19, 2019). "Removing portraits — a mistaken approach to promoting diversity in medicine". Boston Globe. Retrieved February 6, 2023.
  43. ^ Wadman, Meredith (February 3, 2023). "David Sabatini, biologist fired for sexual misconduct, lands millions from private donors to start new lab". Science. Retrieved February 6, 2023.
  44. ^ "Flier and Maratos-Flier Research Lab at Beth Israel Deaconess Medical Center".
  45. ^ "Sarah Flier, MD, Joins BIDMC". 1 September 2010. Retrieved 2010-09-29.
  46. ^ "Jeffrey S. Flier, MD, Receives American Diabetes Association's Distinguished Research Award" (PDF). 9 June 2008. Archived from the original (PDF) on 9 March 2012. Retrieved 2010-10-18.
  47. ^ "Graduation Ceremony, McEwan Hall: Honorary Graduate: Jeffrey S. Flier". 2010. Archived from the original on 2020-01-10. Retrieved 2010-10-18.
  48. ^ "NIDDK Welcomes Five New Members to Advisory Council". 11 March 2005. Archived from the original on 20 December 2010. Retrieved 2010-10-18.
  49. ^ "Jeffrey S. Flier". scholar.google.com. Retrieved 2022-06-18.

External links

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