KIF4A
| KIF4A | |||
|---|---|---|---|
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
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| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr X: 70.29 – 70.42 Mb | Chr X: 99.67 – 99.77 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Kinesin family member 4A is a protein that in humans is encoded by the KIF4A gene.[5][6]
Function
Kinesins, such as KIF4A, are microtubule-based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division.[6]
Interactions
KIF4A has been shown to
Clinical significance
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000090889 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034311 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 46074226.
- ^ a b "Entrez Gene: KIF4A kinesin family member 4A".
- PMID 12809554.
- PMID 15148359.
- PMID 23150796.
- PMID 35312737.
Further reading
- Sekine Y, Okada Y, Noda Y, Kondo S, Aizawa H, Takemura R, Hirokawa N (October 1994). "A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally". The Journal of Cell Biology. 127 (1): 187–201. PMID 7929562.
- Yan RT, Wang SZ (April 1997). "Increased chromokinesin immunoreactivity in retinoblastoma cells". Gene. 189 (2): 263–267. PMID 9168136.
- Tang Y, Winkler U, Freed EO, Torrey TA, Kim W, Li H, et al. (December 1999). "Cellular motor protein KIF-4 associates with retroviral Gag". Journal of Virology. 73 (12): 10508–10513. PMID 10559369.
- Oh S, Hahn H, Torrey TA, Shin H, Choi W, Lee YM, et al. (September 2000). "Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1493 (1–2): 219–224. PMID 10978527.
- Lee YM, Lee S, Lee E, Shin H, Hahn H, Choi W, Kim W (December 2001). "Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis". The Biochemical Journal. 360 (Pt 3): 549–556. PMID 11736643.
- Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. PMID 12809554.
- Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. PMID 12927788.
- Lee YM, Kim W (February 2004). "Kinesin superfamily protein member 4 (KIF4) is localized to midzone and midbody in dividing cells". Experimental & Molecular Medicine. 36 (1): 93–97. PMID 15031677.
- Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–2729. PMID 15148359.
- Kurasawa Y, Earnshaw WC, Mochizuki Y, Dohmae N, Todokoro K (August 2004). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation". The EMBO Journal. 23 (16): 3237–3248. PMID 15297875.
- Mazumdar M, Sundareshan S, Misteli T (August 2004). "Human chromokinesin KIF4A functions in chromosome condensation and segregation". The Journal of Cell Biology. 166 (5): 613–620. PMID 15326200.
- Zhu C, Jiang W (January 2005). "Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis". Proceedings of the National Academy of Sciences of the United States of America. 102 (2): 343–348. PMID 15625105.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. PMID 16344560.
- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–5396. PMID 16565220.
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. S2CID 14294292.
External links
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