Keith Matthews (biologist)
Keith Roland Matthews sleeping sickness | |
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| Scientific career | |
| Fields | |
| Institutions | |
| Thesis | Metacyclic VSG gene activation in Trypanosoma brucei rhodesiense (1990) |
| Doctoral advisor | David Barry |
| Website | Official website  |
Keith Roland Matthews,
Early life and career
Matthews took a B.Sc. in
Trypanosoma brucei rhodesiense.[2][4] In 1990, he became NATO Fellow (Epidemiology and Public Health) at Yale University before moving to the University of Manchester in 1992, where he set up his own laboratory four years later. In 2004, he relocated to the University of Edinburgh, where he has been Professor of Parasite Biology since 2007. He is also Director of the Centre for Immunity, Infection, and Evolution (CIIE), Head of Institute for Immunology and Infection Research (IIIR), and a Wellcome Trust Senior Investigator.[2][5]
Research interests
Matthews researches African trypanosomes and how these parasites communicate to optimize their survival and transmission. In particular, he has researched how trypanosomes change from a "slender" form (to increase
parasitaemia) into a "stumpy" form that is better adapted for transmission to and survival in tsetse flies.[6]
Awards
Matthews was awarded the 2008
Fellow of the Royal Society of Edinburgh in 2014, Fellow of the Academy of Medical Sciences in 2018, and Fellow of the Royal Society in 2020.[2] According to his Academy of Medical Sciences citation, Matthews' work "has led to fundamental breakthroughs in our understanding of the molecular mechanisms that control trypanosome transmission and virulence".[5]
Selected publications
- Ivens, Alasdair C.; Peacock, Christopher S.; Worthey, Elizabeth A.; Murphy, Lee; Aggarwal, Gautam; et al. (15 July 2005). "The Genome of the Kinetoplastid Parasite, Leishmania major". Science. 309 (5733): 436–442. PMID 16020728.
- Matthews, Keith R. (15 January 2005). "The developmental cell biology of Trypanosoma brucei". Journal of Cell Science. 118 (2): 283–290. PMID 15654017.
- Matthews, K R; Tschudi, C; Ullu, E (15 February 1994). "A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes". Genes & Development. 8 (4): 491–501. PMID 7907303. Retrieved 18 September 2022.
References
- . Retrieved 18 September 2022.
- ^ a b c d "Fellow Detail: Keith Matthews". The Royal Society. Retrieved 18 September 2022.
- ^ "Professor Keith Matthews: Professor Keith Matthews". The Royal Society of Edinburgh. Retrieved 18 September 2022.
- ^ Matthews, K (1990). "Metacyclic VSG gene activation in Trypanosoma brucei rhodesiense". WorldCat. University of Glasgow. Retrieved 19 September 2022.
- ^ a b "Professor Keith Matthews". Academy of Medical Sciences. Retrieved 18 September 2022.
- PMID 24294594.
External links
| International | |
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| Academics | |