Keratin 17
| KRT17 | |||
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Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
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| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 17: 41.62 – 41.62 Mb | Chr 11: 100.15 – 100.15 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.[5][6][7][8]
Keratin 17 is a
type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to PC-K17 (previously known as Jackson-Lawler) type pachyonychia congenita and steatocystoma multiplex.[8]
Interactions
Keratin 17 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000128422 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035557 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 1873772.
- PMID 1281771.
- PMID 16831889.
- ^ a b "Entrez Gene: KRT17 keratin 17".
- S2CID 4427026.
Further reading
- Flohr T, Buwitt U, Bonnekoh B, Decker T, Böttger EC (1992). "Interferon-gamma regulates expression of a novel keratin class I gene". Eur. J. Immunol. 22 (4): 975–9. S2CID 85892865.
- Trask DK, Band V, Zajchowski DA, Yaswen P, Suh T, Sager R (1990). "Keratins as markers that distinguish normal and tumor-derived mammary epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2319–23. PMID 1690428.
- Kartasova T, Cornelissen BJ, Belt P, van de Putte P (1987). "Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes". Nucleic Acids Res. 15 (15): 5945–62. PMID 2442723.
- Takahashi K, Folmer J, Coulombe PA (1994). "Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin". J. Cell Biol. 127 (2): 505–20. PMID 7523421.
- Munro CS, Carter S, Bryce S, Hall M, Rees JL, Kunkeler L, Stephenson A, Strachan T (1995). "A gene for pachyonychia congenita is closely linked to the keratin gene cluster on 17q12-q21". J. Med. Genet. 31 (9): 675–8. PMID 7529318.
- Leigh IM, Navsaria H, Purkis PE, McKay IA, Bowden PE, Riddle PN (1995). "Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro". Br. J. Dermatol. 133 (4): 501–11. S2CID 85097321.
- Smith FJ, Corden LD, Rugg EL, Ratnavel R, Leigh IM, Moss C, Tidman MJ, Hohl D, Huber M, Kunkeler L, Munro CS, Lane EB, McLean WH (1997). "Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex". J. Invest. Dermatol. 108 (2): 220–3. PMID 9008238.
- Covello SP, Smith FJ, Sillevis Smitt JH, Paller AS, Munro CS, Jonkman MF, Uitto J, McLean WH (1999). "Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2". Br. J. Dermatol. 139 (3): 475–80. S2CID 22421872.
- McGowan KM, Coulombe PA (1998). "Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development". J. Cell Biol. 143 (2): 469–86. PMID 9786956.
- Schön M, Benwood J, O'Connell-Willstaedt T, Rheinwald JG (1999). "Human sweat gland myoepithelial cells express a unique set of cytokeratins and reveal the potential for alternative epithelial and mesenchymal differentiation states in culture". J. Cell Sci. 112 (12): 1925–36. PMID 10341211.
- Celebi JT, Tanzi EL, Yao YJ, Michael EJ, Peacocke M (1999). "Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2". J. Invest. Dermatol. 113 (5): 848–50. PMID 10571744.
- Smith FJ, Coleman CM, Bayoumy NM, Tenconi R, Nelson J, David A, McLean WH (2001). "Novel keratin 17 mutations in pachyonychia congenita type 2". J. Invest. Dermatol. 116 (5): 806–8. PMID 11348474.
- Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. PMID 11591653.
- Hashiguchi T, Yotsumoto S, Shimada H, Terasaki K, Setoyama M, Kobayashi K, Saheki T, Kanzaki T (2002). "A novel point mutation in the keratin 17 gene in a Japanese case of pachyonychia congenita type 2". J. Invest. Dermatol. 118 (3): 545–7. PMID 11874497.
- Terrinoni A, Smith FJ, Didona B, Canzona F, Paradisi M, Huber M, Hohl D, David A, Verloes A, Leigh IM, Munro CS, Melino G, McLean WH (2002). "Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita". J. Invest. Dermatol. 117 (6): 1391–6. PMID 11886499.
- Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. PMID 12429849.
- van de Rijn M, Perou CM, Tibshirani R, Haas P, Kallioniemi O, Kononen J, Torhorst J, Sauter G, Zuber M, Köchli OR, Mross F, Dieterich H, Seitz R, Ross D, Botstein D, Brown P (2003). "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome". Am. J. Pathol. 161 (6): 1991–6. PMID 12466114.