Leslie Barnett
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Leslie Barnett | |
|---|---|
| Born | 12 October 1920 London, England |
| Died | 10 February 2002 (aged 81) |
| Other names | Margaret Leslie Collard |
| Occupation | Molecular biologist |
| Known for | Frameshift mutations |
Leslie Barnett (born 12 October 1920 as Margaret Leslie Collard – died 10 February 2002)[1] was a British biologist who worked with Francis Crick, Sydney Brenner, and Richard J. Watts-Tobin to genetically demonstrate the triplet nature of the code of protein translation through the Crick, Brenner, Barnett, Watts-Tobin et al. experiment of 1961, which discovered frameshift mutations; this insight provided early elucidation of the nature of the genetic code.
In her professional life, Barnett was a microbiologist who joined the
Career
Early career
At the beginning of the Second World War, she had started training in the Institute of Agriculture in Essex; but in 1939 took a job in
Barnett came to work as a technician in the MRC Unit
On Brenner's retirement in 1986, Barnett left the LMB to work for him in the new MRC Molecular Genetics Unit in Addenbrooke's Hospital. She trained the late Francis Crick in experimental work on phage and assisted him.
Barnett also helped set up Sydney Brenner's laboratory in Singapore, many years later.
Later career
Barnett was amongst the early Fellows elected to join Clare Hall, the newly founded graduate college. In 1972, she became a tutor for graduate students; in 1975, she took over the leading role of Senior Tutor, which she held until her retirement in 1985. She was remembered by hundreds of students of various nationalities, ages and subjects for her "steadfast care, wisdom in solving their problems, and motherly love."[2]
Barnett played a leading role in college affairs, particularly in the organising of social events and parties and will be remembered with great affection by her colleagues and other friends associated with the college. As a token of her contribution to the college the Governing Body has named a student residence the Leslie Barnett House, and a bronze head by the late Lois Tilbrook represents another tribute to her on the site. On retirement she was elected to an Emeritus Fellowship and attended regularly until her last illness.[2]
Tributes
Eric Miller, who was a visiting scientist at the Molecular Biology Laboratory in 1986–87, wrote: "Leslie Barnett should be recognised for her immense scientific contributions to the field of gene structure and function. Professionally, to which I am sure Francis Crick and Sydney Brenner will attest, many of the seminal discoveries in molecular biology would not have occurred without the careful hand, watchful eye and steadfast focus that Leslie brought to the bench and experiments." Francis Crick said: "Alex Rich and I engaged Leslie in 1955 to do some x-ray calculations for us, since in those days electronic computers were still very primitive. After we discovered that Leslie had biological qualifications she did various types of experimental work. Among other things she worked with us on the phase-shift mutants of phage T4. She was invaluable, as she was always such a careful and meticulous experimentalist."[2]
Scientific papers
- Brenner, S., Benzer, S., and Barnett, L. 1958. "Distribution of proflavin-induced mutations in the genetic fine structure", Nature 182: 983–5.
- Brenner, S. and Barnett, L. 1959 "Genetic and chemical studies on the head protein of bacteriophages T2 and T4', in Structure and Function of Genetic Elements. Report of Symposium Held June 1–3, 1959. Brookhaven Symposia 12 (Upton, NY: Brookhaven National Laboratory).
- Brenner, S., Barnett, L., Crick, F.H.C. and Orgel, A. 1961 "The theory of mutangensis", The Journal of Molecular Biology 3: 121–4.
- Crick, F.H.C., Barnett, L., Brenner, S. and Watts-Tobin, R.J. 1961. "General nature of the genetic code for proteins", Nature 192: 1227–32.
- Karn, J., Brenner, S., and Barnett, L. 1983. "Protein structural domains in the Caenorhabditis elegans unc-54 myosin heavy chain gene are not separated by introns", Proceedings of the National Academy of Sciences 80(14): 4253–4257.
- Karn, J., Brenner, S., Barnett, L., and Cesareni, G. 1980. "Novel bacteriophage lambda cloning vector", Proceedings of the National Academy of Sciences 77(9): 5172–5176.
Recognition
In 1978 at Clare Hall a second neighbouring house in Cambridge, now called Leslie Barnett House, was obtained for graduate student accommodation; it was named after the popular Senior Tutor.
Sources
- ISBN 0-9540278-0-9
- ISBN 0-521-57078-6
- ISBN 0-465-09138-5
- Georgina Ferry; 'Max Perutz and the Secret of Life', (Chatto & Windus 2007) 352pp, ISBN 978-0-7011-7695-2. For uncaptionned picture.
- John Finch; 'A Nobel Fellow On Every Floor', Medical Research Council 2008, 381 pp, ISBN 978-1-84046-940-0; this book is all about the MRC Laboratory of Molecular Biology, Cambridge.
- ISBN 0-87969-947-7.
- Horace Freeland Judson, "The Eighth Day of Creation. Makers of the Revolution in Biology"; Penguin Books 1995, first published by Jonathan Cape, 1977; ISBN 0-14-017800-7.
- ISBN 978-0-87969-798-3, published on 25 August 2009.
- ISBN 978-0-87969-864-5. For captioned picture.
- ISBN 978-0-00-721331-3.