Linopristin/flopristin
| Combination of | |
|---|---|
| Linopristin | Antibiotic |
| Flopristin | Antibiotic |
| Clinical data | |
| Other names | NXL103; XRP 2868 |
| Identifiers | |
| CAS Number | |
Linopristin/flopristin (development codes NXL103 and XRP 2868) is an experimental drug candidate under development by Novexel. It is an oral streptogramin antibiotic that has potent in vitro activity against certain Gram-positive bacteria including methicillin resistant Staphylococcus aureus (MRSA),[1] as well as the important respiratory pathogens including penicillin-, macrolide- and quinolone-resistant strains.[2][3] It is a combination of linopristin and flopristin.[4]
Clinical trials
Positive results have been reported from a phase II trial comparing it with amoxicillin.[2] Another phase II trial began in 2010 comparing it with linezolid for treatment of acute bacterial skin and skin structure infections (ABSSSI).[5] No development activity has been reported since 2015.[6]
References
- PMID 20112172.
- ^ a b Novexel Reports Positive Phase II Trial Results With NXL103 in Adult Patients With Community Acquired Pneumonia Archived 2017-07-11 at the Wayback Machine, drugs.com
- PMID 17065630.
- ^ NXL103 at Novexel.com Archived 2011-07-14 at the Wayback Machine
- ^ Clinical trial number NCT00949130 for "Comparative Study of NXL103 Versus Linezolid in Adults With Acute Bacterial Skin and Skin Structure Infections (ABSSSI)" at ClinicalTrials.gov
- ^ "Linopristin/flopristin". Adis Insight.
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