List of target antigens in pemphigus
Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigus.
| Pemphigus variant | Antibody isotype | Antigen | Molecular weight ( KDa )
|
|---|---|---|---|
Mucosal pemphigus vulgaris |
IgG | Desmoglein 3 |
130 |
Mucocutaneous pemphigus vulgaris |
IgG | Desmoglein 1 |
130 160 |
| Pemphigus foliaceus | IgG | Desmoglein 1 |
160 |
| Paraneoplastic pemphigus | IgG | Alpha-2-macroglobulin-like-1 |
130 160 230 500 250 210 210 190 170 |
Drug-induced pemphigus |
IgG | Desmoglein 1 |
130 160 |
Subcorneal pustular dermatosis type of IgA pemphigus |
IgA1 |
Desmocollin 1 |
110/100 |
Intraepidermal neutrophilic type of IgA pemphigus |
IgA1 |
Unknown | |
| Pemphigus erythematosus (Senear–Usher syndrome)[nb 3] | IgG | Desmoglein 1 |
160 |
Fogo selvagem |
IgG | Desmoglein 1 |
160 |
| Pemphigus vegetans | IgG | Desmoglein 3 |
130 |
Pemphigus vegetans of Hallopeau[nb 4] |
IgG | Desmoglein 3 |
130 |
Pemphigus vegetans of Neumann[nb 4] |
IgG | Desmoglein 3 |
130 |
| Pemphigus herpetiformis | IgG | Desmoglein 1 |
130 160 |
Footnotes
- BPAG2
- II autoantibodies have also been reported in Stevens–Johnson syndrome
- ^ Parentheticals are used to indicate other names by which a condition is known. If there are multiple alternative names for a condition, they are separated by commas within the parenthetical.
- ^ Pemphigus vegetans of Neumann represents a severe form of pemphigus vegetans.
See also
- List of target antigens in pemphigoid
- List of conditions caused by problems with junctional proteins
- List of immunofluorescence findings for autoimmune bullous conditions
- List of cutaneous conditions
- List of genes mutated in cutaneous conditions
- List of histologic stains that aid in diagnosis of cutaneous conditions
References
- Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
- James, William D.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.