Malcolm Dixon (biochemist)

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Malcolm Dixon
Frederick Hopkins
Doctoral students

Malcolm Dixon (18 April 1899 – 7 December 1985) was a British biochemist.

Education and early life

Dixon was born in

Frederick Gowland Hopkins.[4]

Research and career

Dixon's research investigated the purification of

apoprotein, the substrate and inhibitor specificity, and the effect of pH
on the kinetic constants.

Dixon was an expert on the theory and use of manometers.

lachrymators and mustard gas and proposed a phosphokinase theory to explain their mode of action.[11]

Dixon proposed a widely used way of plotting enzyme inhibition data, commonly known as the Dixon plot, in which reciprocal rate is plotted against the inhibitor concentration.[12] Rather confusingly, the same name is sometimes given to a quite different plot proposed by Dixon in the same year for analysing pH dependences, in which the logarithm of a Michaelis–Menten parameter is plotted against pH.[13]

Enzymes (Dixon & Webb)

Dixon's classic book Enzymes, written with

IUBMB.[17]

Awards and honours

Dixon was elected a

Fellow of the Royal Society (FRS) in 1942[1] and became a Fellow of King's College, Cambridge
in 1950. He died in Cambridge in 1985.

References

  1. ^
    PMID 11616120
    .
  2. ^ a b c d "Chemistry Tree".
  3. Who's Who & Who Was Who. Vol. 2024 (online ed.). A & C Black. (Subscription or UK public library membership
    required.)
  4. ^ Dixon, Malcolm (1925). The types of oxidation-reduction system, enzymic and non-enzymic, present in living animal tissues (PhD thesis). University of Cambridge.
  5. PMID 16743909
    .
  6. doi:10.1098/rspb.1936.0004
    .
  7. PMID 16743533
    .
  8. doi:10.1016/0005-2787(65)90557-5
    .
  9. PMID 14838904
    .
  10. doi:10.1098/rspb.1931.0066
    .
  11. PMID 16748083.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  12. PMID 13093635
    .
  13. PMID 13093634
    .
  14. ^ Dixon, M; Webb, EC (1958). Enzymes (1st ed.). London: Longmans, Green, and Co.
  15. ^ Dixon, M; Webb, EC (1964). Enzymes (2nd ed.). London: Longmans, Green, and Co.
  16. ISBN 978-0122183584
    .
  17. ^ Nomenclature Committee of the International Union of Biochemistry and Molecular Biology, Enzyme Nomenclature: https://www.qmul.ac.uk/sbcs/iubmb/enzyme/
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