Brian S. Hartley

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For the mathematician Brian Hartley (1939–1994), see Brian Hartley.

Brian Hartley
Born
Brian Selby Hartley

(1926-04-16)16 April 1926[6]
Rawtenstall, Lancashire, England
Died3 May 2021(2021-05-03) (aged 95)
Alma mater
Awards
Scientific career
ThesisThe chemistry and biochemistry of certain organic phosphorus esters with special reference to the inhibition of chymotrypsin (1952)
Doctoral advisor
Doctoral students
Websiteroyalsociety.org/people/brian-hartley-11577

Brian Selby Hartley (16 April 1926 – 3 May 2021)[7] FRS[1] was a British biochemist. He was Professor of Biochemistry at Imperial College London from 1974 to 1991.[1][2]

Education

Hartley was educated at Queens' College, Cambridge graduating with a Bachelor of Arts in 1947 followed by a Master of Arts degree in 1952.[6] He moved to the University of Leeds where he was awarded a PhD in 1952[8] for research supervised by Malcolm Dixon and Bernard A. Kilby.[3][2]

Career and research

From 1952 to 1964, Hartley pioneered work on the sequence and mechanism of the enzyme

Laboratory of Molecular Biology (LMB), and collaborated with David Mervyn Blow[11] in determining the structure and mechanism of chymotrypsin, as part of extensive work on chymotrypsin and related enzymes.[12][13][14]
[15] [16] His group also showed that mammalian serine proteases, including the blood clotting cascade, had homologous structures and mechanisms, indicating a common evolutionary origin.[17] Hartley also studied other enzymes, such as aminoacyl tRNA synthetases (with Alan Fersht),[18][19] xylose isomerase[20] and glucose isomerase.[21]

In 1974, Hartley became Head of the Department of Biochemistry at Imperial College London, converting it into a centre for

bioethanol from waste hemicellulosic biomass, using genetically engineered compost heap microorganisms.[1]

Awards and honours

Hartley was elected a

pancreatic proteolytic enzymes have revealed interesting homologies, which give information about the biological origin of the proteins and their mode of action.[1]
His earlier kinetic studies on chymotrypsin demonstrated the formation of an
acyl enzyme as an intermediate in the hydrolysis reaction.[22]

References

  1. ^ a b c d e f "Professor Brian Hartley FRS". London: Royal Society. Archived from the original on 24 November 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --"Royal Society Terms, conditions and policies". Archived from the original on 25 September 2015. Retrieved 9 March 2016.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
  2. ^
    S2CID 19975592
    .
  3. ^ a b c "Chemistry Tree – Brian S. Hartley Family Tree". academictree.org. Archived from the original on 30 December 2015.
  4. PMID 24532658
    .
  5. OCLC 500526968
    .
  6. ^ a b "HARTLEY, Prof. Brian Selby". Who's Who. Vol. 2015 (online Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
  7. ^ "Brian Hartley (1926 – 2021)". 7 May 2021.
  8. OCLC 500526968
    .
  9. S2CID 4287417
    .
  10. PMID 5971783
    .
  11. S2CID 4214520
    .
  12. PMID 13727969
    .
  13. PMID 14400122
    .
  14. PMID 14400120
    .
  15. S2CID 4216808
    .
  16. S2CID 11398820
    .
  17. S2CID 32023040
    .
  18. PMID 891985
    .
  19. PMID 1109585
    .
  20. PMID 8424759
    .
  21. PMID 11150612
    .
  22. ^ "Certificate of election EC/1971/10: EC/1971/10". London: Royal Society. Archived from the original on 5 August 2014.


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