Methasterone
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Other names | Superdrol; Methyldrostanolone; Methasteron; 2α,17α-Dimethyl-4,5α-dihydrotestosterone; 2α,17α-Dimethyl-DHT; 2α,17α-Dimethyl-5α-androstan-17β-ol-3-one |
Routes of administration | oral |
Drug class | Androgen; Anabolic steroid |
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Pharmacokinetic data | |
Bioavailability | ≈50%[citation needed] |
Metabolism | Liver |
Elimination half-life | 8–12 hours |
Excretion | Urine |
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Methasterone, also known as methyldrostanolone and known by the nickname Superdrol, is a
Medical uses
Methasterone was never a commercially available prescription drug. Its non-17α-alkylated counterpart, drostanolone propionate, was commercialized by Syntex Corporation under the brand name Masteron.[1]
Non-medical uses
Methasterone resurfaced in 2005 as a "designer steroid".
Side effects
Methasterone is
Chemistry
Methasterone, also known as 2α,17α-dimethyl-5α-dihydrotestosterone (2α,17α-dimethyl-DHT) or as 2α,17α-dimethyl-5α-androstan-17β-ol-3-one, is a
Mebolazine is formed by hydrazone formation between two equivalents of methasterone with one equivalent of hydrazine.
History
The synthesis of methasterone is first mentioned in the literature in 1956 in connection with research conducted by Syntex Corporation in order to discover a compound with anti-tumor properties.[9] In a 1959 research journal article, it is initially mentioned and is elaborated upon where its method of synthesis is discussed in greater detail, its tumor inhibiting properties are verified, and it is noted as being a "potent orally active anabolic agent exhibiting only weak androgenic activity."[10] The results of subsequent assays to determine methasterone's anabolic and androgenic activity were published in Vida's Androgens and Anabolic Agents, a dated but still standard reference, where it was noted that methasterone possessed the oral bioavailability of methyltestosterone while being 400% as anabolic and 20% as androgenic, yielding a Q-ratio (anabolic to androgenic ratio) of 20, which is considered very high.[11]
Designer steroid
It was in late 2005 that the reclassification of methasterone as AAS (as well as that of four other designer steroids) was brought to public awareness via an article published in the Washington Post.[12] Don Catlin of the UCLA Olympic Laboratory, who conducted the studies, noted methasterone's similarity to drostanolone. A warning by the FDA was issued soon after to the general public as well as to the distributor, Designer Supplements LLC, for the marketing of this compound.[13] Methasterone was subsequently added to the World Anti-Doping Agency (WADA) list of prohibited substances in sport.[14] Despite all of this, methasterone has resurfaced within the supplement industry on several occasions since its banning by WADA.[15]
References
- ^ "Superdrol, masteron en oxy komen uit hetzelfde nest" [Superdrol, Masteron, and Oxy come from the same nest]". Ergogenics.org. Retrieved 21 February 2009.
- S2CID 33621513.
- ^ "Implementation of the Anabolic Steroid Control Act of 2004". Office of Division Control, Drug Enforcement Administration, Department of Justice. Archived from the original on 16 February 2012. Retrieved 21 February 2009.
- ^ Shipley A, Berkowitz B, Rivero C (October 18, 2005). "Designer Steroids Hide and Seek". The Washington Post. Retrieved 21 February 2009.
- S2CID 5889075.
- S2CID 21819008.
- PMID 18187367.
- PMID 18813027.
- .
- .
- ^ Vida JA (1969). Androgens and Anabolic Agents: Chemistry and Pharmacology. New York: Academic Press. pp. 23 & 168.
- ^ Shipley A (November 30, 2005). "Steroids Detected in Dietary Tablets". The Washington Post. Retrieved 21 February 2009.
- ^ "FDA Warns Manufacturers About Illegal Steroid Products Sold as Dietary Supplements". U.S. Food and Drug Administration. March 9, 2006. Retrieved 21 February 2009.
- ^ "The World Anti-Doping Code: The 2009 Prohibited List: International Standard" (PDF). World Anti-Doping Agency. Archived from the original (PDF) on 2009-02-03. Retrieved 21 February 2009.
- ^ Epstein D, Dohrmann G (May 18, 2009). "What You Don't Know Might Kill You: Would-be experts and untested products feed a $20 billion obsession with better performance across all levels of sports". Sports Illustrated. Archived from the original on April 16, 2014. Retrieved June 14, 2011.