Methylchloroisothiazolinone

Source: Wikipedia, the free encyclopedia.
Methylchloroisothiazolinone
Skeletal formula of methylchloroisothiazolinone
Space-filling model of the methylchloroisothiazolinone molecule
Names
Preferred IUPAC name
5-Chloro-2-methyl-1,2-thiazol-3(2H)-one
Other names
5-Chloro-2-methylisothiazol-3(2H)-one
5-Chloro-2-methyl-4-isothiazolin-3-one
Chloromethylisothiazolinone
Chloromethylisothiazolone
Methylchloroisothiazolinone
Methylchloroisothiazolone
CMI
CMIT
MCI
MCIT
CIT
Identifiers
3D model (
JSmol
)
1210149
ChEBI
ChemSpider
DrugBank
ECHA InfoCard
 100.043.167 Edit this at Wikidata
EC Number
  • 247-500-7
UNII
  • InChI=1S/C4H4ClNOS/c1-6-4(7)2-3(5)8-6/h2H,1H3 checkY
    Key: DHNRXBZYEKSXIM-UHFFFAOYSA-N checkY
  • InChI=1/C4H4ClNOS/c1-6-4(7)2-3(5)8-6/h2H,1H3
    Key: DHNRXBZYEKSXIM-UHFFFAOYAV
  • ClC=1SN(C(=O)C=1)C
Properties
C4H4ClNOS
Molar mass 149.59 g·mol−1
Appearance white solid
Density 1.02 g/cm3
Melting point 52 °C (126 °F; 325 K)
Miscible
Hazards
GHS labelling:
GHS05: CorrosiveGHS06: ToxicGHS07: Exclamation markGHS09: Environmental hazard
Danger
H300, H301, H310, H311, H314, H317, H330, H331, H335, H410
P260, P261, P262, P264, P270, P271, P272, P273, P280, P284, P301+P310, P301+P330+P331, P302+P350, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P311, P312, P320, P321, P322, P330, P333+P313, P361, P363, P391, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Methylchloroisothiazolinone, also referred to as MCI, is the

fungi
.

Application

Methylchloroisothiazolinone is found in many water-based personal care products and cosmetics.[2] Methylchloroisothiazolinone was first used in cosmetics in the 1970s. It is also used in glue production, detergents, paints, fuels, and other industrial processes. Methylchloroisothiazolinone is known by the registered tradename Kathon CG when used in combination with methylisothiazolinone.[3]

Methylchloroisothiazolinone may be used in combination with other preservatives including ethylparaben, benzalkonium chloride, bronopol and phenoxyethanol.

Hazards

Methylchloroisothiazolinone can cause allergic reactions in some people.[4] The first publication of the preservative as a contact allergen was in 1988.[5] Cases of photoaggravated allergic contact dermatitis, i.e. worsening of skin lesions after sun exposure, have also been reported.[4]

In pure form or in high concentrations, methylchloroisothiazolinone is a skin and membrane irritant and causes chemical burns. In the United States, maximum authorized concentrations are 15 ppm in rinse-offs (of a mixture in the ratio 3:1 of 5-chloro-2-methylisothiazol 3(2H)-one and 2-methylisothiazol-3 (2H)-one).[6] In Canada, methylchloroisothiazolinone may only be used in rinse-off products in combination with methylisothiazolinone, the total concentration of the combination may not exceed 15 ppm.[7]

References

  1. PMID 32102175
    .
  2. ^
    S2CID 21296570
    .
  3. ^
    PMID 2321281
    .
  4. ^
    S2CID 37257050
    .
  5. PMID 3279090
    .
  6. ^ "Annex VI release - 26 November 2017 - 201703" (PDF). U.S. Food and Drug Administration.
  7. ^ "Cosmetic Ingredient Hotlist: Prohibited and Restricted Ingredients". Health Canada. 18 June 2004. Retrieved 15 February 2020.

External links

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