Min Chueh Chang

Source: Wikipedia, the free encyclopedia.

The native form of this personal name is Chang Min-chueh. This article uses Western name order when mentioning individuals.
Min Chueh Chang
Reproductive biologist
Known forHis work in in vitro fertilisation and the combined oral contraceptive pill
SpouseIsabelle Chang
Children3

Min Chueh Chang (

Worcester Foundation for Experimental Biology
.

Education and private life

Chang was born on October 10, 1908, in the village of Dunhòu (敦厚), which lies 64 miles (103 km) northwest of

John Hammond and F.H.A. Marshall, under the tutelage of Arthur Walton. In 1941, he was awarded a PhD in animal breeding
by the University of Cambridge on his observations on the effect of testicular cooling and various hormonal treatments on the respiration, metabolism, and survival of sperm in animals.

Chang met his wife, American-born Chinese Isabelle Chin Chang, in the library at Yale University, shortly after he moved to the United States.[2] Chin assumed the role of the housewife in the pair's marriage, allowing Chang to delve into his work without domestic concerns.[2] They have two daughters and a son together – Claudia Chang Tourtellotte, head of the anthropology department at Sweet Briar College;[4] Pamela O'Malley Chang, an architect, civil engineer, and sustainable design consultant[5] and Francis Hugh Chang, director of health centers in Boston, Massachusetts.[2] and San Jose, California.[6]

Upon his death, Chang was buried in

Worcester Foundation for Experimental Biology was located.[2]

Worcester Foundation for Experimental Biology

Main article:
Worcester Foundation for Experimental Biology

In March 1945, Chang arrived at the recently founded Worcester Foundation of Experimental Biology in

in vitro fertilisation. It was apparent that they worked well together and Chang would eventually spend the rest of his career at the foundation, researching mammalian fertilisation. Funds became increasingly available for research on reproduction from the 1950s, and the Foundation attracted a number of talented scientists. Chang guided and advised these scientists, may of whom would go on to become leaders in the field of reproduction. While at the Foundation Chang's work contributed to the development of the oral contraceptive, making him one of the co-founders of the combined oral contraceptive pill.[2]

Professional achievements

One of Chang's notable achievements was his research and testing of the effectiveness of certain orally administered

eggs, and the fertilisation process itself. The ability to control the fertility of eggs was a necessity to his work. He initiated the study of orally administered contraceptives for mammals to enable him to better conduct his research in fertilisation. Indeed, throughout the span of his 45-year career, only five years, 1951 to 1956, were spent researching and testing the effectiveness of orally administered contraceptives, and this work was mainly on the oral mode of the administration of the contraceptive steroids, rather than on the effectiveness of the steroids themselves, which had already been previously proven.[2]

Chang's body of work in mammalian fertilisation is large and appears in nearly 350 publications. One of his major discoveries was the effect of lowering temperature on sperm. Chang found that at a temperature of 13 °C or lower, the membrane structure and function of sperm would disintegrate, thus destroying the fertilising capacity of the sperm. This phenomenon is now commonly known as

female reproductive tract. The process of capacitation, the maturation period of sperm that is required in order for them to be able to fertilise ova, was also one of Chang's major discoveries. This observation would lead him further to find that capacitated sperm would lose capacitation if exposed to seminal plasma or blood serum, and that recapacitation could be achieved if the sperm was placed back in the uterus or the fallopian tubes.[2]

Of all his research and experimentation, Chang's work in

test tube baby" in 1978.[2]

Awards and honours

References

  1. ^ Zhào Zhì Zhōng (赵志忠), ed. (2004) Father of the Test Tube Baby: Chang Min Chueh (试管婴儿之父: 张民觉). Hohhot, Inner Mongolia, China: Yuanfang Publishing House, page 37 [in Chinese]. Geographic coordinates of Dunhòu: 38°9′50″North, 111°26′38″East
  2. ^ a b c d e f g h i j k l m Biographical Memoir of Min Chueh Chang, National Academy of Science. Retrieved on March 24, 2021.
  3. ^ The Cambridge University List of Members 1976
  4. ^ Anthropology Program Faculty Archived June 15, 2006, at the Wayback Machine, Sweet Briar College. Retrieved on February 25, 2007.
  5. ^ Article "Eco-Clean Homes" by Pamela O'Malley Chang Archived April 27, 2006, at the Wayback Machine, Mindfully.org, Spring 2003. Retrieved on February 25, 2007.
  6. ^ aaci.org http://aaci.org/main/about/management-team/. Retrieved January 28, 2016. {{cite web}}: Missing or empty |title= (help)[title missing]
  7. ^ List of recipients, Albert Lasker Awards Given by Planned Parenthood – World Population Archived October 13, 2006, at the Wayback Machine, The Lasker Foundation. Retrieved on February 25, 2007
  8. ^ List of recipients, Carl G. Hartman Award Archived August 4, 2007, at the Wayback Machine, Society for the Study of Reproduction. Retrieved on February 25, 2007

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Min_Chueh_Chang&oldid=1206950226"