Mitotic index

Mitotic index is defined as the ratio between the number of a population's cells undergoing mitosis to its total number of cells.

Purpose

The mitotic index is a measure of cellular proliferation.^[1]

It is defined as the percentage of cells undergoing mitosis in a given population of cells. Mitosis is the division of

The mitotic index is the number of cells undergoing mitosis divided by the total number of cells.[4]

A typical figure of mitotic index includes statements like "10 mitotic figures are noted per 10 high power fields" followed by "4 mitotic figures noted per 50 high power fields."

Formula

${\displaystyle {\mbox{Mitotic I}}={\frac {\mbox{(P+M+A+T)}}{\mbox{N}}}\cdot 100\%}$

where (P+M+A+T) is the sum of all cells in phase as prophase, metaphase, anaphase and telophase, respectively and N is total number of cells.

Examples

The fastest rate of mitosis happens in the zygote, embryo and infant stage for humans and animals because mitosis is essential for embryological development. Mitosis is also required at a higher rate to grow and repair tissue. Some examples include human lymph nodes and bone marrow. Also, skin, hair, and the cells lining the intestines (epithelial cells) have high rates of mitosis. That's because those tissues constantly need to be repaired (by the cells being replaced) or growing. Plants have higher rates of mitosis at the cells of the shoot and root tips.

References

External links

• Beresford, Mark J.; Wilson, George D.; Makris, Andreas (2006). "Measuring proliferation in breast cancer". Breast Cancer Research. 8 (6): 216.
  PMID 17164010
  .
• van Diest, PJ; van der Wall, E; Baak, JP (2004). "Prognostic value of proliferation in invasive breast cancer". J. Clin. Pathol. 57 (7): 675–81.
  PMID 15220356
  .
• "NCI Dictionary of Cancer terms". cancer.gov. 2011-02-02.

https://heimduo.org/which-tissues-have-the-highest-rate-of-mitosis/

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