N-Nitrosodiethylamine

Source: Wikipedia, the free encyclopedia.
Not to be confused with N-Nitrosodimethylamine.
N-Nitrosodiethylamine
Ball-and-stick model of nitrosodiethylamine
Names
Preferred IUPAC name
Diethylnitrous amide
Other names
N-Ethyl-N-nitrosoethanamine
Diethylnitrosamine
DENA
NDEA
Identifiers
3D model (
JSmol
)
ChEBI
ChemSpider
ECHA InfoCard
 100.000.206 Edit this at Wikidata
EC Number
  • 214-237-4
KEGG
MeSH D004052
UNII
  • InChI=1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3
    Key: WBNQDOYYEUMPFS-UHFFFAOYSA-N
  • CCN(CC)N=O
Properties
C4H10N2O
Molar mass 102.137 g·mol−1
Appearance Yellow liquid[1]
Density 0.95 g/mL[1]
Boiling point 177 °C (351 °F; 450 K)[1]
-59.3·10−6 cm3/mol
Related compounds
Related compounds
 Diethylamine, N-Nitrosodimethylamine
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

N-Nitrosodiethylamine (NDEA) is an

DNA damage repair and mitochondrial genome maintenance in yeast.[4]

It is found in tobacco smoke.[5][6]

It is classified as a

Group 2A carcinogen (probable human carcinogen) by the World Health Organization.[7]

NDEA involvement in recalls

In the year 2019, NDEA was found as an impurity in

U.S. Food and Drug Administration has confirmed levels of NDEA and/or NDMA exceeding the interim acceptable intake limits, and the affected medicines were recalled.[8]

References

  1. ^ a b c "N-Nitrosodiethylamine". Sigma-Aldrich.
  2. ^ "N-Nitrosodiethylamine". PubChem. National Center for Biotechnology Information. May 8, 2021. Retrieved May 12, 2021.
  3. PMID 8910949
    .
  4. ^ Ogbede, J.U., Giaever, G. & Nislow, C. A genome-wide portrait of pervasive drug contaminants. Sci Rep 11, 12487 (2021). https://doi.org/10.1038/s41598-021-91792-1
  5. PMID 1995191
    .
  6. PMID 21556207
    .
  7. ^ "List of Classifications, Volumes 1-115". IARC Monographs on the Evaluation of Risk to Humans. International Agency for Research on Cancer. February 22, 2016. Archived from the original on June 10, 2017. Retrieved July 26, 2016.
  8. U.S. Food and Drug Administration
    . November 7, 2019. Retrieved May 12, 2021.
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