NOL12
| NOL12 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 22: 37.68 – 37.69 Mb | Chr 15: 78.82 – 78.83 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Nucleolar protein 12 is a
Nol12 Family
Human Nol12 belongs to family of proteins known as ribosomal binding proteins RBPs. The human members have equivalents in different species. Its homologue in Drosophila melanogaster is called Viriato which is involved in eye and nervous system development and without Viriato, Drosophila melanogaster eye development fails. Loss of also Viriato resulted in cell proliferation, developmental delays and apoptosis.[9][10] hNOL12 homologue in rats is known as Nop25 and is responsible for nucleolar structure and integrity.[11] Its yeast homologue has been named as Rrp17 which has been shown to possess 5′-3′ exonuclease activity and is involved in ribosome biogenesis.[12]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000273899 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033099 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 12477932.
- ^ "Entrez Gene: NOL12 nucleolar protein 12".
- PMID 30988155.
- PMID 29069457.
- PMID 23416177.
- S2CID 18287789.
- PMID 17524363.
- PMID 20005841.
Further reading
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. S2CID 7827573.
- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. PMID 16565220.
- Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. PMID 15461802.
- Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, et al. (January 2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Research. 13 (1): 27–36. PMID 12529303.
- Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. PMID 10591208.
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