Norman Lowther Edson
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Norman L Edson | |
---|---|
Born | 1 March 1904 |
Died | 12 May 1970 (aged 66) |
Nationality | New Zealand |
Alma mater | University of New Zealand |
Known for | Ketone body metabolism, Metabolic pathways of mycobacteria, Polyol metabolism |
Spouse | Suzanne Moor |
Awards | Beit Memorial Fellowship 1933 Fellow of the Royal Society of New Zealand |
Scientific career | |
Fields | Biochemistry |
Institutions | University of New Zealand Faculty of Medicine, University of Cambridge, England |
Thesis | Studies in Intermediary Metabolism (1936) |
Doctoral advisor | Joseph Needham, Hans Krebs |
Notable students | Richard Kulka, John Exton |
Norman Lowther Edson (1 March 1904 – 12 May 1970),
Edson made contributions to knowledge of cellular intermediary
Early life
Edson was the only surviving child of Norman Percival Edson (1868–1908), a pharmacist, and Phoebe, née Moses, a photographic colourist. Following her husband's early death, Phoebe Edson did not remarry but devoted herself to caring for her only child. Family money provided a comfortable home.
At Auckland Grammar School Edson won a Junior National Scholarship (1921) and was in the top ten Scholars for New Zealand.[2] He entered the University of Otago School of Medicine in 1922, and his mother moved to Dunedin to housekeep for him. In 1927 he graduated Bachelor of Medical Science (BMedSc), the first to do so. Edson had a distinguished undergraduate career gaining four prizes and graduated in 1930 MB ChB with distinction.[3] Edson excelled at hockey and represented his school, university, province and New Zealand.[4]
Marriage and family
Edson married Suzanne Moor (1917–2009), a medical student, in 1938. Edson was 34, Suzanne 21. They had three children.
Postgraduate education
After graduating Edson spent two years jointly in the Departments of Chemistry and of Physiology at Otago University and received a Certificate of Proficiency in Chemistry in 1932 with a thesis on catalysis of oxybenzoic acids.[5] Also as Assistant Lecturer in Physiology he gave practical classes and lectured on biochemistry. By then he had decided biochemistry was his subject. From this period Edson published two papers.[6][7]
In 1933 Edson won a Beit Memorial Medical Fellowship and spent two years at
In Cambridge, under Krebs' mentorship Edson conducted an extensive investigation on the metabolism of
Krebs, in his reminiscences, refers to Edson twice: "With Norman Edson, a medical graduate and PhD student from New Zealand, I studied the formation of
Edson also befriended Luis Federico Leloir and collaborated with him on ketogenesis.[9] Edson dedicated his 1966 paper on glucogenesis from sorbitol to LeLoir to celebrate Leloir's 60th birthday.[12] Edson also became acquainted with Ernst Chain and D D Wood.
In 1935 Edson attended the 15th International Congress of Physiology at Moscow. He subsequently told of hearing Ivan Pavlov speak and the destitution in the Moscow streets with the hungry placing their noses against the window looking at the plenty on the tables on the other side.[citation needed]
From Edson's Cambridge work came seven papers, all published in the Biochemical Journal. Two papers were co-authored with Krebs, on the micro-determination of uric acid and on the avian synthesis of uric acid; one with LeLoir on ketone metabolism.[13] The four where he was the sole author were on ketogenesis.[14]
Academic life in New Zealand
Upon his return from Cambridge Edson was appointed Lectuter in Biochemistry at the University of Otago Medical School. He set up a modern biochemistry department for teaching and research. Initially he provided his own equipment and chemicals but later was supported by the Travis Trust for Tuberculosis Research. Fortunately in 1943 John Eccles, a noted neurophysiologist, was appointed to the chair of physiology. Eccles recognised Edson's talents and gave him full support in his enterprises (Eccles, 1977).[15] Gradually Edson recruited a small staff and a number of research students who assisted in his teaching and research.
His early work in New Zealand was devoted to the delineation of metabolic pathways of Mycobacteria, relatives of the tuberculosis bacterium. He used the innovative approach of studying cell extracts which gave a clearer picture of bacterial metabolic pathways than whole cells, then currently in use (Edson, 1951).[16]
In the 1950s, he and his students turned their attention to the metabolism of the polyols (sugar alcohols). They carried out an extensive survey of the diversity of the polyol dehydrogenases and determined rules for the steric specificity of these enzymes. (McCorkindale and Edson, 1954; Arcus and Edson, 1956).[17]
References
- ^ Batt, R.D., "Norman Lowther Edson 1904–1970". Proceedings of the Royal Society of New Zealand, 1970. 99: p. 106-110.
- ^ Trembarth, K.A., Ad Augusta Per Angusta: A Centennial History of Auckland Grammar School 1869–1969. 1969, Auckland: Auckland Grammar School Old Boy's Association.
- ^ Carmalt Jones, D.W., Annals of the University of Otago Medical School 1875–1939. 1945, Wellington: Reed.
- ^ Otago University Students Association, Men's Hockey. Otago University Review, 1926–28, 1932.
- ^ Edson, N.L., "Catalytic hydrogenation of oxybenzoic acids", in Chemistry. 1932, Otago University.
- ^ Edson, N.L., "The catalytic hydrogenation of the hydroxybenzoic acids in aqueous solution". Journal of the Society of Chemical Industry, 1934. 53(19): p. 138-139.
- ^ Edson, N.L., "The liver pigments of New Zealand oysters and toheroas". New Zealand Journal of Science and Technology, 1934. 15(6): p. 395-397.
- ^ Edson, N.L., "Studies in Intermediary Metabolism", in Faculty of Biology 'B'. Biochemistry. 1936, Cambridge: Cambridge.
- ^ PMID 16746295]
- ^ Edson N.L., Krebs H.A. and Model A. 1936 The synthesis of uric acid in the avian organism: Hypoxanthine as an intermediary metabolite. Biochem. J. 30: 1380–1385; Edson N.L.1946 Biological synthesis of purines and pyrimidines. Aust. J. Sci. 9:102–107
- ^ a b Krebs H.A. 1981 "Reminiscences and Reflections", Clarendon Press, Oxford.
- ^ a b Loten, E.G., I.L. MacGregor, and N.L. Edson, "Glucogenesis from sorbitol U-14C in liver slices of starved rats". Archives of Biochemistry and Biophysics, 1966. 116: p. 352-357.
- ^ Edson, N.L., H.A. Krebs, and A. Model, "The synthesis of uric acid in the avian organism: hypoxanthine as an intermediary metabolite". Biochemical Journal, 1936. 30: p. 1380-1385. Edson, N.L. and H.A. Krebs, "Micro-determination of uric acid". Biochemical Journal, 1936. 30: p. 732-735. Edson, N.L. and L.F. LeLoir, "Ketogenesis-antiketogenesis: Metabolism of ketone bodies". Biochemical Journal, 1936. 30: p. 2319-32.
- ^ Edson, N.L., "Ketogenesis-antiketogenesis: Ketogenesis from amino-acids". Biochemical Journal, 1935. 29: p. 2498-505. Edson, N.L., "Ketogenesis-antiketogenesis: The influence of ammonium chloride on ketone-body formation in liver". Biochemical Journal, 1935. 29: p. 2082-94. Edson, N.L., "Ketogenesis-antiketogenesis: Substrate competition in liver". Biochemical Journal, 1936. 30: p. 1862-1869. Edson, N.L., "Ketogenesis-antiketogenesis: Metabolism of aldehydes and dicarboxylic acids". Biochemical Journal, 1936. 30.: p. 1855-1861.
- ^ Eccles J.C. 1977 My Scientific Odyssey Annu. Rev. Physiol. 39: 1–18.
- PMID 14886295]
- PMID 13373782]