Oxepanoprolinamide
Oxepanoprolinamides are a class of antibiotics. They include iboxamycin.[1] These drugs are fully synthetic. The molecules contain the aminooctose component of clindamycin. They were developed by Andrew G. Myers and Yury S. Polikanov.[1] The structure contains an oxepane (a seven-membered ring compound with oxygen) and a proline, with an amide group that increases rigidity.[2]
Oxepanoprolinamides function by insertion into bacterial
antibiotic resistance to clindamycin based on Erm and Cfr ribosomal RNA methyltransferase enzymes.[1][3][4]