PA2G4
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Proliferation-associated protein 2G4 (PA2G4) also known as ErbB3-binding protein 1 (EBP1) is a protein that in humans is encoded by the PA2G4 gene.[5]
Function
This gene encodes an
ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional corepressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Paradoxically, the expression of EBP1 is decreased in prostate cancer,[6] but increased in Acute Myelogneous Leukemia.[7] Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.[8]
Interactions
PA2G4 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000170515 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025364 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9345902.
- PMID 18852121.
- PMID 26813358.
- ^ "Entrez Gene: PA2G4 proliferation-associated 2G4, 38kDa".
- S2CID 43143635.
- PMID 10682683.
- S2CID 42721280.
- PMID 12165860.
Further reading
- Radomski N, Jost E (October 1995). "Molecular cloning of a murine cDNA encoding a novel protein, p38-2G4, which varies with the cell cycle". Experimental Cell Research. 220 (2): 434–45. PMID 7556453.
- Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. PMID 8889548.
- Froesch BA, Takayama S, Reed JC (May 1998). "BAG-1L protein enhances androgen receptor function". The Journal of Biological Chemistry. 273 (19): 11660–6. PMID 9565586.
- Kim ST, Lim DS, Canman CE, Kastan MB (December 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members". The Journal of Biological Chemistry. 274 (53): 37538–43. PMID 10608806.
- Yoo JY, Wang XW, Rishi AK, Lessor T, Xia XM, Gustafson TA, Hamburger AW (February 2000). "Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin". British Journal of Cancer. 82 (3): 683–90. PMID 10682683.
- Lessor TJ, Yoo JY, Xia X, Woodford N, Hamburger AW (June 2000). "Ectopic expression of the ErbB-3 binding protein ebp1 inhibits growth and induces differentiation of human breast cancer cell lines". Journal of Cellular Physiology. 183 (3): 321–9. S2CID 1973521.
- Xia X, Cheng A, Lessor T, Zhang Y, Hamburger AW (May 2001). "Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation". Journal of Cellular Physiology. 187 (2): 209–17. S2CID 42721280.
- Lessor TJ, Hamburger AW (April 2001). "Regulation of the ErbB3 binding protein Ebp1 by protein kinase C". Molecular and Cellular Endocrinology. 175 (1–2): 185–91. S2CID 43143635.
- Xia X, Lessor TJ, Zhang Y, Woodford N, Hamburger AW (November 2001). "Analysis of the expression pattern of Ebp1, an ErbB-3-binding protein". Biochemical and Biophysical Research Communications. 289 (1): 240–4. PMID 11708806.
- Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. S2CID 14132033.
- Zhang Y, Fondell JD, Wang Q, Xia X, Cheng A, Lu ML, Hamburger AW (August 2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609–18. PMID 12165860.
- Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (November 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. PMID 12429849.
- Zhang Y, Woodford N, Xia X, Hamburger AW (April 2003). "Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases". Nucleic Acids Research. 31 (8): 2168–77. PMID 12682367.
- Squatrito M, Mancino M, Donzelli M, Areces LB, Draetta GF (May 2004). "EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes". Oncogene. 23 (25): 4454–65. PMID 15064750.
- Zhang Y, Hamburger AW (June 2004). "Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription". The Journal of Biological Chemistry. 279 (25): 26126–33. PMID 15073182.
- Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. PMID 15231747.
- Zhang Y, Hamburger AW (January 2005). "Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling". British Journal of Cancer. 92 (1): 140–6. PMID 15583694.
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